TY - JOUR
T1 - Evidence of some natural products with antigenotoxic effects. Part 1
T2 - Fruits and polysaccharides
AU - Izquierdo-Vega, Jeannett Alejandra
AU - Morales González, José Antonio
AU - Sánchez-Gutiérrez, Manuel
AU - Betanzos-Cabrera, Gabriel
AU - Sosa-Delgado, Sara M.
AU - Sumaya-Martínez, María Teresa
AU - Morales-González, Ángel
AU - Paniagua-Pérez, Rogelio
AU - Madrigal-Bujaidar, Eduardo
AU - Madrigal-Santillán, Eduardo
N1 - Publisher Copyright:
© 2017 by the authors.
PY - 2017/2/2
Y1 - 2017/2/2
N2 - Cancer is one of the leading causes of deaths worldwide. The agents capable of causing damage to genetic material are known as genotoxins and, according to their mode of action, are classified into mutagens, carcinogens or teratogens. Genotoxins are involved in the pathogenesis of several chronic degenerative diseases including hepatic, neurodegenerative and cardiovascular disorders, diabetes, arthritis, cancer, chronic inflammation and ageing. In recent decades, researchers have found novel bioactive phytocompounds able to counteract the effects of physical and chemical mutagens. Several studies have shown potential antigenotoxicity in a variety of fruits. In this review (Part 1), we present an overview of research conducted on some fruits (grapefruit, cranberries, pomegranate, guava, pineapple, and mango) which are frequently consumed by humans, as well as the analysis of some phytochemicals extracted from fruits and yeasts which have demonstrated antigenotoxic capacity in various tests, including the Ames assay, sister chromatid exchange, chromosomal aberrations, micronucleus and comet assay.
AB - Cancer is one of the leading causes of deaths worldwide. The agents capable of causing damage to genetic material are known as genotoxins and, according to their mode of action, are classified into mutagens, carcinogens or teratogens. Genotoxins are involved in the pathogenesis of several chronic degenerative diseases including hepatic, neurodegenerative and cardiovascular disorders, diabetes, arthritis, cancer, chronic inflammation and ageing. In recent decades, researchers have found novel bioactive phytocompounds able to counteract the effects of physical and chemical mutagens. Several studies have shown potential antigenotoxicity in a variety of fruits. In this review (Part 1), we present an overview of research conducted on some fruits (grapefruit, cranberries, pomegranate, guava, pineapple, and mango) which are frequently consumed by humans, as well as the analysis of some phytochemicals extracted from fruits and yeasts which have demonstrated antigenotoxic capacity in various tests, including the Ames assay, sister chromatid exchange, chromosomal aberrations, micronucleus and comet assay.
KW - Antigenotoxic
KW - Cancer
KW - Chromosomal aberrations
KW - Comet assay
KW - Fruits
KW - Micronucleus
KW - Polysaccharides
UR - http://www.scopus.com/inward/record.url?scp=85012154546&partnerID=8YFLogxK
U2 - 10.3390/nu9020102
DO - 10.3390/nu9020102
M3 - Artículo de revisión
SN - 2072-6643
VL - 9
JO - Nutrients
JF - Nutrients
IS - 2
M1 - 102
ER -