TY - JOUR
T1 - Evidence for the involvement of nitric oxide in the antinociceptive effect of ketorolac
AU - Granados-Soto, Vinicio
AU - Flores-Murrieta, Francisco J.
AU - Castañeda-Hernández, Gilberto
AU - López-Muñoz, Francisco J.
PY - 1995/4/24
Y1 - 1995/4/24
N2 - The involvement of nitric oxide in the antinociception produced by ketorolac was assessed using the pain-induced functional impairment model in the rat: 800 μg of NG-nitro-l-arginine methyl ester, an inhibitor of nitric oxide synthesis, or saline was injected intra-articularly in a hind limb joint previously injured with uric acid. Animals then received ketorolac, dipyrone or no drug. Ketorolac and dipyrone produced a significant antinociceptive effect which was reduced by pretreatment with NG-nitro-l-arginine methyl ester, but not with saline. It is concluded that the antinociceptive effect of both drugs involves the local participation of nitric oxide.
AB - The involvement of nitric oxide in the antinociception produced by ketorolac was assessed using the pain-induced functional impairment model in the rat: 800 μg of NG-nitro-l-arginine methyl ester, an inhibitor of nitric oxide synthesis, or saline was injected intra-articularly in a hind limb joint previously injured with uric acid. Animals then received ketorolac, dipyrone or no drug. Ketorolac and dipyrone produced a significant antinociceptive effect which was reduced by pretreatment with NG-nitro-l-arginine methyl ester, but not with saline. It is concluded that the antinociceptive effect of both drugs involves the local participation of nitric oxide.
KW - Dipyrone
KW - Ketorolac tromethamine
KW - N-Nitro-l-arginine methyl ester
KW - Nitric oxide (NO)
UR - http://www.scopus.com/inward/record.url?scp=0028938061&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(95)00123-3
DO - 10.1016/0014-2999(95)00123-3
M3 - Artículo
SN - 0014-2999
VL - 277
SP - 281
EP - 284
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2-3
ER -