TY - JOUR
T1 - Evaluation of some plant-derived secondary metabolites against sensitive and multidrug-resistant Mycobacterium tuberculosis
AU - Del Rayo Camacho-Corona, María
AU - De Jesús Favela-Hernández, Juan Manuel
AU - González-Santiago, Omar
AU - Garza-González, Elvira
AU - Molina-Salinas, Gloria María
AU - Said-Fernández, Salvador
AU - Delgado, Guillermo
AU - Luna-Herrera, Julieta
PY - 2009
Y1 - 2009
N2 - The results on the bioevaluation of thirty five plant-derived secondary metabolites against one sensitive and three multidrugresistant clinical isolates of Mycobacterium tuberculosis are reported. Results toward the sensitive strain showed that five products gave MIC values of 12.5 μg/mL: the alkaloids 6-methoxydihydrochelerytrine (2) and 6-methoxy-dihydrochelirubine (6), the flavanone pinostrobin (17), 1-hydroxy-benzoisochromanquinone (23) and 23-hydroxy-5a-lanosta-7,9(11),24-triene-3-one (33). These were followed by the peracetylstrictosidine lactam (12) and the quinone aloe-emodin (24) which displayed MICs of 6.25 μg/mL. Finally, liriodenine (8) was the most active (MIC: 3.125 μg/mL) of all secondary metabolites. Results with the multidrug-resistant clinical isolates showed that 6-methoxy-dihydrochelirubine (6) was the most active (MIC: 12.5 μg/mL).
AB - The results on the bioevaluation of thirty five plant-derived secondary metabolites against one sensitive and three multidrugresistant clinical isolates of Mycobacterium tuberculosis are reported. Results toward the sensitive strain showed that five products gave MIC values of 12.5 μg/mL: the alkaloids 6-methoxydihydrochelerytrine (2) and 6-methoxy-dihydrochelirubine (6), the flavanone pinostrobin (17), 1-hydroxy-benzoisochromanquinone (23) and 23-hydroxy-5a-lanosta-7,9(11),24-triene-3-one (33). These were followed by the peracetylstrictosidine lactam (12) and the quinone aloe-emodin (24) which displayed MICs of 6.25 μg/mL. Finally, liriodenine (8) was the most active (MIC: 3.125 μg/mL) of all secondary metabolites. Results with the multidrug-resistant clinical isolates showed that 6-methoxy-dihydrochelirubine (6) was the most active (MIC: 12.5 μg/mL).
KW - Alkaloids
KW - Antituberculosis activity
KW - Bioactive secondary metabolites
KW - Diterpenes
KW - Flavonoids
KW - Mycobacterium tuberculosis
KW - Quinones
KW - Triterpenes
UR - http://www.scopus.com/inward/record.url?scp=77952917752&partnerID=8YFLogxK
M3 - Artículo
SN - 1870-249X
VL - 53
SP - 71
EP - 75
JO - Journal of the Mexican Chemical Society
JF - Journal of the Mexican Chemical Society
IS - 2
ER -