Eumycetoma caused by Cladophialophora bantiana successfully treated with itraconazole

Alexandro Bonifaz; Sybren Hoog; Michael Mcginnis; Amado Saúl; Octavio Rodríguez-Cortés; Javier Araiza; Mariana Cruz; Patricia Mercadillo

doi:10.1080/13693780802430639

Eumycetoma caused by Cladophialophora bantiana successfully treated with itraconazole

Alexandro Bonifaz, Sybren Hoog, Michael Mcginnis, Amado Saúl, Octavio Rodríguez-Cortés, Javier Araiza, Mariana Cruz, Patricia Mercadillo

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A 57-year-old male presented with dermatosis of the dorsum of the foot consisting of tumefaction, deformity and sinus tract formation. The direct examination of exudates as well as the biopsy tissue, demonstrated the presence of black granules. A dematiaceous fungus was isolated from the lesions and was identified by ribosomal DNA sequencing as Cladophialophora bantiana. This is the second report of this fungus as an etiologic agent of eumycetoma in humans. Clinical and mycologic cure was achieved after 20 months of treatment with itraconazole at a starting dose of 300 mg/day that was tapered during the course of therapy. The patient's isolate had an itraconazole MIC of 0.012μg/ml.

Original language	English
Pages (from-to)	111-114
Number of pages	4
Journal	Medical Mycology
Volume	47
Issue number	1
DOIs	https://doi.org/10.1080/13693780802430639
State	Published - 2009
Externally published	Yes

Keywords

Cladophialophora bantiana
Eumycetoma
Itraconazole
Mycetoma
Phaeohyphomycosis

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10.1080/13693780802430639

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title = "Eumycetoma caused by Cladophialophora bantiana successfully treated with itraconazole",

abstract = "A 57-year-old male presented with dermatosis of the dorsum of the foot consisting of tumefaction, deformity and sinus tract formation. The direct examination of exudates as well as the biopsy tissue, demonstrated the presence of black granules. A dematiaceous fungus was isolated from the lesions and was identified by ribosomal DNA sequencing as Cladophialophora bantiana. This is the second report of this fungus as an etiologic agent of eumycetoma in humans. Clinical and mycologic cure was achieved after 20 months of treatment with itraconazole at a starting dose of 300 mg/day that was tapered during the course of therapy. The patient's isolate had an itraconazole MIC of 0.012μg/ml.",

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T1 - Eumycetoma caused by Cladophialophora bantiana successfully treated with itraconazole

AU - Bonifaz, Alexandro

AU - Hoog, Sybren

AU - Mcginnis, Michael

AU - Saúl, Amado

AU - Rodríguez-Cortés, Octavio

AU - Araiza, Javier

AU - Cruz, Mariana

AU - Mercadillo, Patricia

PY - 2009

Y1 - 2009

N2 - A 57-year-old male presented with dermatosis of the dorsum of the foot consisting of tumefaction, deformity and sinus tract formation. The direct examination of exudates as well as the biopsy tissue, demonstrated the presence of black granules. A dematiaceous fungus was isolated from the lesions and was identified by ribosomal DNA sequencing as Cladophialophora bantiana. This is the second report of this fungus as an etiologic agent of eumycetoma in humans. Clinical and mycologic cure was achieved after 20 months of treatment with itraconazole at a starting dose of 300 mg/day that was tapered during the course of therapy. The patient's isolate had an itraconazole MIC of 0.012μg/ml.

AB - A 57-year-old male presented with dermatosis of the dorsum of the foot consisting of tumefaction, deformity and sinus tract formation. The direct examination of exudates as well as the biopsy tissue, demonstrated the presence of black granules. A dematiaceous fungus was isolated from the lesions and was identified by ribosomal DNA sequencing as Cladophialophora bantiana. This is the second report of this fungus as an etiologic agent of eumycetoma in humans. Clinical and mycologic cure was achieved after 20 months of treatment with itraconazole at a starting dose of 300 mg/day that was tapered during the course of therapy. The patient's isolate had an itraconazole MIC of 0.012μg/ml.

KW - Cladophialophora bantiana

KW - Eumycetoma

KW - Itraconazole

KW - Mycetoma

KW - Phaeohyphomycosis

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U2 - 10.1080/13693780802430639

DO - 10.1080/13693780802430639

M3 - Artículo

C2 - 19031337

SN - 1369-3786

VL - 47

SP - 111

EP - 114

JO - Medical Mycology

JF - Medical Mycology

IS - 1

ER -

Eumycetoma caused by Cladophialophora bantiana successfully treated with itraconazole

Abstract

Keywords

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