(-)-Epicatechin reduces adiposity in male offspring of obese rats

Sergio De Los Santos, Luis Antonio Reyes-Castro, Ramón Mauricio Coral-Vázquez, Juan Pablo Méndez, Marcela Leal-García, Elena Zambrano, Patricia Canto

Research output: Contribution to journalArticle

Abstract

Objective:To determine whether (-)-epicatechin (Epi) could decrease visceral adipose tissue and improve the metabolic profile of male offspring rats, after maternal obesity was induced by a high-fat diet (HFD).Design:Maternal obesity in albino Wistar rats was induced with a HFD, whereas male offspring were fed with chow diet throughout the study. Eight male offspring per group, from different litters, were randomly assigned to the experimental or to the control groups. In the experimental group, Epi was administered at a dose of 1 mg/kg of body weight to the male offspring twice daily for two weeks, beginning at postnatal day (PND).Main measures:Weight of visceral adipose tissue, adipocyte size, and several metabolic parameters.Results:Epi administration in the male offspring induced a significant decrease in the amount of visceral fat (11.61 g less, P < 0.05) and in the size of adipose cells (28% smaller, P < 0.01). Besides, Epi was able to decrease insulin, leptin, and Homeostasis Model Assessment -Insulin Resistance (HOMA-IR) (P < 0.05), as well as triglycerides, when the experimental group was compared to the untreated male offspring of obese rats (P < 0.01).Conclusions:Epi administration can reverse the negative effects that maternal obesity has on the male offspring. This could be because Epi reduces the amount of visceral fat and improves metabolic profile.

Original languageEnglish
JournalJournal of Developmental Origins of Health and Disease
DOIs
StateAccepted/In press - 1 Jan 2019

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Catechin
Adiposity
Intra-Abdominal Fat
Metabolome
Obesity
Mothers
High Fat Diet
Leptin
Cell Size
Adipocytes
Insulin Resistance
Wistar Rats
Triglycerides
Homeostasis
Body Weight
Insulin
Diet
Weights and Measures
Control Groups

Keywords

  • (-)-epicatechin
  • male offspring
  • maternal obesity
  • rats

Cite this

De Los Santos, S., Reyes-Castro, L. A., Coral-Vázquez, R. M., Méndez, J. P., Leal-García, M., Zambrano, E., & Canto, P. (Accepted/In press). (-)-Epicatechin reduces adiposity in male offspring of obese rats. Journal of Developmental Origins of Health and Disease. https://doi.org/10.1017/S2040174419000345
De Los Santos, Sergio ; Reyes-Castro, Luis Antonio ; Coral-Vázquez, Ramón Mauricio ; Méndez, Juan Pablo ; Leal-García, Marcela ; Zambrano, Elena ; Canto, Patricia. / (-)-Epicatechin reduces adiposity in male offspring of obese rats. In: Journal of Developmental Origins of Health and Disease. 2019.
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(-)-Epicatechin reduces adiposity in male offspring of obese rats. / De Los Santos, Sergio; Reyes-Castro, Luis Antonio; Coral-Vázquez, Ramón Mauricio; Méndez, Juan Pablo; Leal-García, Marcela; Zambrano, Elena; Canto, Patricia.

In: Journal of Developmental Origins of Health and Disease, 01.01.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - (-)-Epicatechin reduces adiposity in male offspring of obese rats

AU - De Los Santos, Sergio

AU - Reyes-Castro, Luis Antonio

AU - Coral-Vázquez, Ramón Mauricio

AU - Méndez, Juan Pablo

AU - Leal-García, Marcela

AU - Zambrano, Elena

AU - Canto, Patricia

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N2 - Objective:To determine whether (-)-epicatechin (Epi) could decrease visceral adipose tissue and improve the metabolic profile of male offspring rats, after maternal obesity was induced by a high-fat diet (HFD).Design:Maternal obesity in albino Wistar rats was induced with a HFD, whereas male offspring were fed with chow diet throughout the study. Eight male offspring per group, from different litters, were randomly assigned to the experimental or to the control groups. In the experimental group, Epi was administered at a dose of 1 mg/kg of body weight to the male offspring twice daily for two weeks, beginning at postnatal day (PND).Main measures:Weight of visceral adipose tissue, adipocyte size, and several metabolic parameters.Results:Epi administration in the male offspring induced a significant decrease in the amount of visceral fat (11.61 g less, P < 0.05) and in the size of adipose cells (28% smaller, P < 0.01). Besides, Epi was able to decrease insulin, leptin, and Homeostasis Model Assessment -Insulin Resistance (HOMA-IR) (P < 0.05), as well as triglycerides, when the experimental group was compared to the untreated male offspring of obese rats (P < 0.01).Conclusions:Epi administration can reverse the negative effects that maternal obesity has on the male offspring. This could be because Epi reduces the amount of visceral fat and improves metabolic profile.

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