TY - JOUR
T1 - Enzymatic reduction of 9-methoxytariacuripyrone by saccharomyces cerevisiae and its antimycobacterial activity
AU - Alvarez-Fitz, Patricia
AU - Alvarez, Laura
AU - Marquina, Silvia
AU - Luna-Herrera, Julieta
AU - Navarro-García, Víctor Manuel
PY - 2012/7
Y1 - 2012/7
N2 - Biotransformation processes have been successfully utilized to obtain products of pharmaceutical, chemical, food, and agricultural interest, which are difficult to obtain by classic chemical methods. The compound with antituberculous activity, 9-methoxy-tariacuripyrone (1), isolated from Aristolochia brevipes, was submitted to biotransformation with the yeast Saccharomyces cerevisiae under culture, yielding 5-amino-9-methoxy-3, 4-dihydro-2H-benzo[h]chromen-2-one (2). The structure of 2 was elucidated on the basis of spectroscopic analyses. The results mainly show the reduction of the double bond and the nitro group of compound 1. Metabolite 2 demonstrated an increase in anti-tuberculous activity (MIC = 3.12 μg/mL) against the drug-sensitive Mycobacterium tuberculosis (H37Rv) strain, with respect to that shown by 1.
AB - Biotransformation processes have been successfully utilized to obtain products of pharmaceutical, chemical, food, and agricultural interest, which are difficult to obtain by classic chemical methods. The compound with antituberculous activity, 9-methoxy-tariacuripyrone (1), isolated from Aristolochia brevipes, was submitted to biotransformation with the yeast Saccharomyces cerevisiae under culture, yielding 5-amino-9-methoxy-3, 4-dihydro-2H-benzo[h]chromen-2-one (2). The structure of 2 was elucidated on the basis of spectroscopic analyses. The results mainly show the reduction of the double bond and the nitro group of compound 1. Metabolite 2 demonstrated an increase in anti-tuberculous activity (MIC = 3.12 μg/mL) against the drug-sensitive Mycobacterium tuberculosis (H37Rv) strain, with respect to that shown by 1.
KW - 9-methoxytariacuripyrone
KW - Antituberculous activity
KW - Biotransformation
KW - Saccharomyces cerevisiae
UR - http://www.scopus.com/inward/record.url?scp=84864580170&partnerID=8YFLogxK
U2 - 10.3390/molecules17078464
DO - 10.3390/molecules17078464
M3 - Artículo
C2 - 22790562
SN - 1420-3049
VL - 17
SP - 8464
EP - 8470
JO - Molecules
JF - Molecules
IS - 7
ER -