TY - JOUR
T1 - Endothelial cells are a potential site of interaction between estrogens and glucocorticoids
AU - Campos-Rodríguez, R.
AU - Rivera-Aguilar, V.
AU - Jarillo-Luna, R. A.
AU - Rojas-Hernández, S.
AU - Godínez-Victoria, M.
AU - Abarca-Rojano, E.
AU - Mera-Jiménez, E.
AU - Larsen, B. A.
AU - Reséndiz-Albor, A. A.
N1 - Funding Information:
This work was supported by SIP-COFAA-IPN (Mexico).
PY - 2009
Y1 - 2009
N2 - Estrogens and glucocorticoids have synergistic effects in the micro and macrovasculature of endothelial cells. Whereas in the former they both have pro-inflammatory effects, in the latter they both inhibit the expression of adhesion molecules. Since the molecular basis of this synergy has not been defined, we propose possible mechanisms of interaction. An understanding of the functional interaction between estrogens and glucocorticoids in the endothelial cells of the micro and macrovasculature may contribute to clarifying the role of the endothelial cells of different vascular beds during the inflammatory response and in chronic inflammation. These advances could contribute to the design of more effective therapeutic strategies for the prevention of diseases, such as atherosclerosis, systemic lupus erythematosus and rheumatoid arthritis, in which the inflammatory process plays an important pathogenic role.
AB - Estrogens and glucocorticoids have synergistic effects in the micro and macrovasculature of endothelial cells. Whereas in the former they both have pro-inflammatory effects, in the latter they both inhibit the expression of adhesion molecules. Since the molecular basis of this synergy has not been defined, we propose possible mechanisms of interaction. An understanding of the functional interaction between estrogens and glucocorticoids in the endothelial cells of the micro and macrovasculature may contribute to clarifying the role of the endothelial cells of different vascular beds during the inflammatory response and in chronic inflammation. These advances could contribute to the design of more effective therapeutic strategies for the prevention of diseases, such as atherosclerosis, systemic lupus erythematosus and rheumatoid arthritis, in which the inflammatory process plays an important pathogenic role.
KW - Autoimmunity diseases
KW - Endothelial cells
KW - Estrogen-receptors
KW - Estrogens
KW - Glucocorticoids
KW - Inflammatory response
UR - http://www.scopus.com/inward/record.url?scp=70049086018&partnerID=8YFLogxK
U2 - 10.1016/j.bihy.2009.05.001
DO - 10.1016/j.bihy.2009.05.001
M3 - Artículo
SN - 1756-2392
VL - 2
SP - 331
EP - 338
JO - Bioscience Hypotheses
JF - Bioscience Hypotheses
IS - 5
ER -