TY - JOUR
T1 - Enantioselective synthesis of either enantiomer of α-alkyl-α- hydroxy-α-phenylacetic acids using chiral auxiliaries
AU - Pérez-Estrada, Salvador
AU - Lagunas-Rivera, Selene
AU - Vargas-Díaz, María Elena
AU - Velázquez-Ponce, Pedro
AU - Joseph-Nathan, Pedro
AU - Zepeda, L. Gerardo
N1 - Funding Information:
L.G.Z. acknowledges CGPI/IPN (grant 20020683, 20030702, and 20040199) and CONACyT-Mexico (35013E, 44157-Q). M.E.V.D. and S.L.R. thank CONACyT-Mexico (92069 and 125225, respectively) and CGPI/IPN (PIFI) postgraduate fellowships. S.P.E. and P.V.P. thank Institutional Fellowship (CGPI/IPN).
PY - 2005/5/23
Y1 - 2005/5/23
N2 - The enantioselective synthesis of either enantiomer of α-alkyl- α-hydroxy-α-phenylacetic acids was achieved by using 2-acyloxathianes 1a-c and the mixed acyl-S,O-acetals 7 and 8 as chiral auxiliaries, which can straightforwardly be prepared from (1R)-(-)-myrtenal. This procedure allowed the preparation of the title compounds in >95% enantiomeric excess (ee).
AB - The enantioselective synthesis of either enantiomer of α-alkyl- α-hydroxy-α-phenylacetic acids was achieved by using 2-acyloxathianes 1a-c and the mixed acyl-S,O-acetals 7 and 8 as chiral auxiliaries, which can straightforwardly be prepared from (1R)-(-)-myrtenal. This procedure allowed the preparation of the title compounds in >95% enantiomeric excess (ee).
UR - http://www.scopus.com/inward/record.url?scp=19344370376&partnerID=8YFLogxK
U2 - 10.1016/j.tetasy.2005.03.032
DO - 10.1016/j.tetasy.2005.03.032
M3 - Artículo
SN - 0957-4166
VL - 16
SP - 1837
EP - 1843
JO - Tetrahedron Asymmetry
JF - Tetrahedron Asymmetry
IS - 10
ER -