TY - JOUR
T1 - El papel de los genes del desarrollo tipo HOX en el cáncer cervicouterino
AU - López-Romero, Ricardo
AU - Marrero-Rodríguez, Daniel
AU - Romero-Morelos, Pablo
AU - Villegas, Vanessa
AU - Valdivia, Alejandra
AU - Arreola, Hugo
AU - Huerta-Padilla, Víctor
AU - Salcedo, Mauricio
PY - 2015
Y1 - 2015
N2 - Cervical cancer (CC) is a multifactorial disease associated to genetic, environmental and epigenetic factors, being the infection by human papillomavirus the main etiologic agent. Additionally, the alteration in the expression of transcription factors has been considered of importance for the development of this tumor. HOX genes encode a group of transcription factors involved in cellular proliferation and differentiation processes during the development of embryonic structures in vertebrates; their aberrant expression is associated with tumorigenesis and metastasis. A range of evidence suggests a role for HOX genes in the development of cervical neoplastic cell. Studies in CC cell lines, primary tumors and premalignant lesions have suggested the involvement of HOXA1, HOXC5, C6, C8 and C10, HOXD9 and HOXD13 in the process of cervical carcinogenesis. Also, the de novo expression of genes HOXB2, B4, B13 and HOXC11-C13 appears to be involved in the process of malignant transformation of cervical epithelial cell. These data would allow to open a field in search of new molecular markers in cervical cancer and the development of new therapeutic strategies for this malignancy.
AB - Cervical cancer (CC) is a multifactorial disease associated to genetic, environmental and epigenetic factors, being the infection by human papillomavirus the main etiologic agent. Additionally, the alteration in the expression of transcription factors has been considered of importance for the development of this tumor. HOX genes encode a group of transcription factors involved in cellular proliferation and differentiation processes during the development of embryonic structures in vertebrates; their aberrant expression is associated with tumorigenesis and metastasis. A range of evidence suggests a role for HOX genes in the development of cervical neoplastic cell. Studies in CC cell lines, primary tumors and premalignant lesions have suggested the involvement of HOXA1, HOXC5, C6, C8 and C10, HOXD9 and HOXD13 in the process of cervical carcinogenesis. Also, the de novo expression of genes HOXB2, B4, B13 and HOXC11-C13 appears to be involved in the process of malignant transformation of cervical epithelial cell. These data would allow to open a field in search of new molecular markers in cervical cancer and the development of new therapeutic strategies for this malignancy.
KW - Homeobox genes
KW - Uterine cervical neoplasms
UR - http://www.scopus.com/inward/record.url?scp=85021851892&partnerID=8YFLogxK
M3 - Artículo de revisión
C2 - 26462515
AN - SCOPUS:85021851892
SN - 0443-5117
VL - 53
SP - S188-S193
JO - Revista Medica del Instituto Mexicano del Seguro Social
JF - Revista Medica del Instituto Mexicano del Seguro Social
ER -