TY - JOUR
T1 - Efficacy of water-based vitamin E solution versus placebo in the prevention of retinopathy of prematurity in very low birth weight infants
T2 - A randomized clinical trial
AU - Romero-Maldonado, Silvia
AU - Montoya-Estrada, Araceli
AU - Reyes-Muñoz, Enrique
AU - Guzmán-Grenfell, Alberto Martín
AU - Torres-Ramos, Yessica Dorin
AU - Sánchez-Mendez, Mario David
AU - Tolentino-Dolores, Maricruz
AU - Salgado-Valladares, Manuel Bernardo
AU - Belmont-Gómez, Aurora
AU - Najéra, Nayelli
AU - Ceballos, Guillermo
AU - Cardona-Pérez, Jorge Arturo
AU - Hicks, Juan José
AU - Mancilla-Ramírez, Javier
N1 - Publisher Copyright:
© 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
PY - 2021/8/6
Y1 - 2021/8/6
N2 - Background:Vitamin E has antioxidant properties, which help in scavenging free radicals, thereby reducing oxidation of lipids and proteins. This study aims to evaluate the efficacy of oral vitamin E supplementation in preventing retinopathy of prematurity (ROP) in very low birth weight (VLBW) infants with respiratory distress syndrome (RDS) and decreasing oxidative stress 15 and 28 days post-intervention.Methods:Ninety VLBW infants were randomly assigned to two groups:1.Treatment (treatment group (T), n = 48) or2.Placebo (control group (C), n = 42).Each group received 25 IU of vitamin E (T) or placebo (C).Results:The incidence of ROP in groups T and C was 12.5% (n=6) and 31% (n = 13), respectively (RR: 0.40; 95% CI: 0.10-0.96). There were no differences in mortality between groups. As expected, the vitamin E concentration was significantly increased 28 days post-intervention in group T.Conclusion:Oral supplementation with vitamin E may effectively prevent ROP development in VLBW infants with RDS. Oxidative damage markers were significantly lower, whereas total antioxidant capacity was increased in group T. However, levels of other antioxidants as vitamin A and C were not measured in two groups.
AB - Background:Vitamin E has antioxidant properties, which help in scavenging free radicals, thereby reducing oxidation of lipids and proteins. This study aims to evaluate the efficacy of oral vitamin E supplementation in preventing retinopathy of prematurity (ROP) in very low birth weight (VLBW) infants with respiratory distress syndrome (RDS) and decreasing oxidative stress 15 and 28 days post-intervention.Methods:Ninety VLBW infants were randomly assigned to two groups:1.Treatment (treatment group (T), n = 48) or2.Placebo (control group (C), n = 42).Each group received 25 IU of vitamin E (T) or placebo (C).Results:The incidence of ROP in groups T and C was 12.5% (n=6) and 31% (n = 13), respectively (RR: 0.40; 95% CI: 0.10-0.96). There were no differences in mortality between groups. As expected, the vitamin E concentration was significantly increased 28 days post-intervention in group T.Conclusion:Oral supplementation with vitamin E may effectively prevent ROP development in VLBW infants with RDS. Oxidative damage markers were significantly lower, whereas total antioxidant capacity was increased in group T. However, levels of other antioxidants as vitamin A and C were not measured in two groups.
KW - antioxidant vitamins
KW - oxidative damage
KW - retinopathy of prematurity
KW - total antioxidant capacity
KW - vitamin E
UR - http://www.scopus.com/inward/record.url?scp=85114522447&partnerID=8YFLogxK
U2 - 10.1097/MD.0000000000026765
DO - 10.1097/MD.0000000000026765
M3 - Artículo
C2 - 34397821
AN - SCOPUS:85114522447
SN - 0025-7974
VL - 100
SP - E26765
JO - Medicine
JF - Medicine
IS - 31
ER -