Abstract
The aim of this work was to analyze the contribution of the Na+-Ca2+ exchanger in the generation of afterdepolarizations in a single cell by simulating the effects of free radicals in the context of ischemiareperfusion, using a modified version of Luo and Rudy II action potential model (LRd model). To simulate the effects of ischemia three conditions were considered: hyperkalemia, acidosis and hypoxia. Simulations were run as long as steady state of all parameters of the model were reached, and then the availability of the Na+-Ca2+ exchanger current (INaCa) was varied. The generation of Delayed After-Depolarizations(DADs) depends on the extra cellular potassium concentration, [K+]o, and on the availability of INaCa. DADs observed during reperfusion period appeared when just a percent of INaCa was used.
| Original language | English |
|---|---|
| Pages (from-to) | 517-520 |
| Number of pages | 4 |
| Journal | Computers in Cardiology |
| Volume | 31 |
| State | Published - 2004 |
| Event | Computers in Cardiology 2004 - Chicago, IL, United States Duration: 19 Sep 2004 → 22 Sep 2004 |