TY - JOUR
T1 - Effects of exercise on oxidative stress in rats induced by ozone
AU - Martinez-Campos, Catalina
AU - Lara-Padilla, Eleazar
AU - Bobadilla-Lugo, Rosa Amalia
AU - Kross, Robert David
AU - Villanueva, Cleva
PY - 2012
Y1 - 2012
N2 - Oxidative stress (OS) induced by acute exercise is reduced by chronic exercise. Ozone (O3) exposure produces OS. The aim of this study was to determine if aerobic exercise (AE) reduced OS produced by O3. A pilot experiment was performed with male Wistar rats submitted to AE (trained to swim 90min/day). Adaptation to exercise was demonstrated three weeks after training by means of changes in reduced nitrates (NO x) in plasma. Therefore, two-week training was chosen for the following experiments. Six of twelve trained rats were exposed to O3 (0.5ppm, 4h/day, one hour before exercise). Two groups of sedentary animals (n = 6 each) were used as controls, one of which was exposed to O3. At the end of the experiments NO x, 8-isoprostane (8-IP), malondialdehyde (MDA), superoxide dismutase (SOD) activity, and carbonyls (CBs) were measured in plasma. CBs did not change in any group. O3-induced OS was manifested by reduced NOx and SOD activity, as well as increased 8-IP and MDA. Exercise significantly blocked O3 effects although SOD was also decreased by exercise (a greater drop occurring in the O3 group). It is concluded that AE protects against OS produced by O3 and the effect is independent of SOD.
AB - Oxidative stress (OS) induced by acute exercise is reduced by chronic exercise. Ozone (O3) exposure produces OS. The aim of this study was to determine if aerobic exercise (AE) reduced OS produced by O3. A pilot experiment was performed with male Wistar rats submitted to AE (trained to swim 90min/day). Adaptation to exercise was demonstrated three weeks after training by means of changes in reduced nitrates (NO x) in plasma. Therefore, two-week training was chosen for the following experiments. Six of twelve trained rats were exposed to O3 (0.5ppm, 4h/day, one hour before exercise). Two groups of sedentary animals (n = 6 each) were used as controls, one of which was exposed to O3. At the end of the experiments NO x, 8-isoprostane (8-IP), malondialdehyde (MDA), superoxide dismutase (SOD) activity, and carbonyls (CBs) were measured in plasma. CBs did not change in any group. O3-induced OS was manifested by reduced NOx and SOD activity, as well as increased 8-IP and MDA. Exercise significantly blocked O3 effects although SOD was also decreased by exercise (a greater drop occurring in the O3 group). It is concluded that AE protects against OS produced by O3 and the effect is independent of SOD.
UR - http://www.scopus.com/inward/record.url?scp=84861050104&partnerID=8YFLogxK
U2 - 10.1100/2012/135921
DO - 10.1100/2012/135921
M3 - Artículo
SN - 2356-6140
VL - 2012
JO - Scientific World Journal
JF - Scientific World Journal
M1 - 135921
ER -