Effects of chronic inhibition of Testosterone metabolism on cardiac remodeling after ischemia/reperfusion-induced myocardial damage in gonadectomized rats

Octavio Maldonado; Angel Ramos; Mario Guapillo; Jose Rivera; Icela Palma; Ivan Rubio-Gayosso; Israel Ramirez-Sanchez; Nayelli Najera; Guillermo Ceballos; Enrique Mendez-Bolaina

doi:10.1242/bio.041905

Effects of chronic inhibition of Testosterone metabolism on cardiac remodeling after ischemia/reperfusion-induced myocardial damage in gonadectomized rats

Octavio Maldonado, Angel Ramos, Mario Guapillo, Jose Rivera, Icela Palma, Ivan Rubio-Gayosso, Israel Ramirez-Sanchez, Nayelli Najera, Guillermo Ceballos, Enrique Mendez-Bolaina

Escuela Superior de Medicina (ESM)

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The effects of testosterone on cardiovascular homeostasis are still not well understood. The objective of this work was to evaluate the effects of testosterone in the absence or presence of inhibition of Aromatase (4-hydroxyandrostenedione) and/or 5α reductase (Finasteride) enzymatic activities on the myocardial remodeling 30 days after ischemia/reperfusion (I/R) injury in gonadectomized rats. Results showed that testosterone administration to ORX rats resulted in decreased myocardial damaged area, inflammatory infiltrates and reduced MMP-3 and 13 expressions. Interestingly, Finasteride administration resulted in a greater decrease in scar tissue, inflammatory infiltrates, along with a significant decrease in MMP-3 and 13 expressions. In contrast, 4-hydroxyandrostenedione administrations increased all parameters. Our results suggest that testosterone does not have a direct effect since simultaneous inhibition of aromatase and 5α-reductase did not induce significant changes in I/R induced myocardial injury.

Original language	English
Article number	bio041905
Journal	Biology Open
Volume	8
Issue number	5
DOIs	https://doi.org/10.1242/bio.041905
State	Published - 2019

Keywords

17β-estradiol
Cardiac remodeling
Cardio-protection
Metalloproteinase
Testosterone

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10.1242/bio.041905

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Maldonado, O., Ramos, A., Guapillo, M., Rivera, J., Palma, I., Rubio-Gayosso, I., Ramirez-Sanchez, I., Najera, N., Ceballos, G., & Mendez-Bolaina, E. (2019). Effects of chronic inhibition of Testosterone metabolism on cardiac remodeling after ischemia/reperfusion-induced myocardial damage in gonadectomized rats. Biology Open, 8(5), Article bio041905. https://doi.org/10.1242/bio.041905

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title = "Effects of chronic inhibition of Testosterone metabolism on cardiac remodeling after ischemia/reperfusion-induced myocardial damage in gonadectomized rats",

abstract = "The effects of testosterone on cardiovascular homeostasis are still not well understood. The objective of this work was to evaluate the effects of testosterone in the absence or presence of inhibition of Aromatase (4-hydroxyandrostenedione) and/or 5α reductase (Finasteride) enzymatic activities on the myocardial remodeling 30 days after ischemia/reperfusion (I/R) injury in gonadectomized rats. Results showed that testosterone administration to ORX rats resulted in decreased myocardial damaged area, inflammatory infiltrates and reduced MMP-3 and 13 expressions. Interestingly, Finasteride administration resulted in a greater decrease in scar tissue, inflammatory infiltrates, along with a significant decrease in MMP-3 and 13 expressions. In contrast, 4-hydroxyandrostenedione administrations increased all parameters. Our results suggest that testosterone does not have a direct effect since simultaneous inhibition of aromatase and 5α-reductase did not induce significant changes in I/R induced myocardial injury.",

keywords = "17β-estradiol, Cardiac remodeling, Cardio-protection, Metalloproteinase, Testosterone",

author = "Octavio Maldonado and Angel Ramos and Mario Guapillo and Jose Rivera and Icela Palma and Ivan Rubio-Gayosso and Israel Ramirez-Sanchez and Nayelli Najera and Guillermo Ceballos and Enrique Mendez-Bolaina",

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Maldonado, O, Ramos, A, Guapillo, M, Rivera, J, Palma, I , Rubio-Gayosso, I , Ramirez-Sanchez, I , Najera, N , Ceballos, G & Mendez-Bolaina, E 2019, 'Effects of chronic inhibition of Testosterone metabolism on cardiac remodeling after ischemia/reperfusion-induced myocardial damage in gonadectomized rats', Biology Open, vol. 8, no. 5, bio041905. https://doi.org/10.1242/bio.041905

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AU - Maldonado, Octavio

AU - Ramos, Angel

AU - Guapillo, Mario

AU - Rivera, Jose

AU - Palma, Icela

AU - Rubio-Gayosso, Ivan

AU - Ramirez-Sanchez, Israel

AU - Najera, Nayelli

AU - Ceballos, Guillermo

AU - Mendez-Bolaina, Enrique

PY - 2019

Y1 - 2019

N2 - The effects of testosterone on cardiovascular homeostasis are still not well understood. The objective of this work was to evaluate the effects of testosterone in the absence or presence of inhibition of Aromatase (4-hydroxyandrostenedione) and/or 5α reductase (Finasteride) enzymatic activities on the myocardial remodeling 30 days after ischemia/reperfusion (I/R) injury in gonadectomized rats. Results showed that testosterone administration to ORX rats resulted in decreased myocardial damaged area, inflammatory infiltrates and reduced MMP-3 and 13 expressions. Interestingly, Finasteride administration resulted in a greater decrease in scar tissue, inflammatory infiltrates, along with a significant decrease in MMP-3 and 13 expressions. In contrast, 4-hydroxyandrostenedione administrations increased all parameters. Our results suggest that testosterone does not have a direct effect since simultaneous inhibition of aromatase and 5α-reductase did not induce significant changes in I/R induced myocardial injury.

AB - The effects of testosterone on cardiovascular homeostasis are still not well understood. The objective of this work was to evaluate the effects of testosterone in the absence or presence of inhibition of Aromatase (4-hydroxyandrostenedione) and/or 5α reductase (Finasteride) enzymatic activities on the myocardial remodeling 30 days after ischemia/reperfusion (I/R) injury in gonadectomized rats. Results showed that testosterone administration to ORX rats resulted in decreased myocardial damaged area, inflammatory infiltrates and reduced MMP-3 and 13 expressions. Interestingly, Finasteride administration resulted in a greater decrease in scar tissue, inflammatory infiltrates, along with a significant decrease in MMP-3 and 13 expressions. In contrast, 4-hydroxyandrostenedione administrations increased all parameters. Our results suggest that testosterone does not have a direct effect since simultaneous inhibition of aromatase and 5α-reductase did not induce significant changes in I/R induced myocardial injury.

KW - 17β-estradiol

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KW - Cardio-protection

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Effects of chronic inhibition of Testosterone metabolism on cardiac remodeling after ischemia/reperfusion-induced myocardial damage in gonadectomized rats

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