TY - JOUR
T1 - Effects of acute sodium fluoride exposure on kidney function, water homeostasis, and renal handling of calcium and inorganic phosphate
AU - Santoyo-Sanchez, Mitzi Paola
AU - Del Carmen Silva-Lucero, Maria
AU - Arreola-Mendoza, Laura
AU - Barbier, Olivier Christophe
N1 - Funding Information:
Acknowledgments This research was supported by the Consejo Nacional de Ciencia y Tecnología (CONACyT, grant 152416) and the Instituto Politécnico Nacional (IPN/SIP grant 20082576), México. M.P. Santoyo-Sanchez was awarded a fellowship from CONACyT (grant 28849).
PY - 2013/6
Y1 - 2013/6
N2 - Fluoride compounds are abundant and widely distributed in the environment at a variety of concentrations. Further, fluoride induces toxic effects in target organs such as the liver and kidney. In this study, we performed an early analysis of renal function using a clearance technique in Wistar rats acutely exposed to fluoride at a plasma concentration of 0.625 μg/ml. Our results revealed that fluoride, at a concentration close to the concentration present in the serum after environmental exposure, induced a significant tubular dysfunction, resulting in diluted urine, impaired protein reabsorption, and increased calcium and phosphate urinary excretion. Our work demonstrates that even acute exposures to low concentrations of NaF may induce renal damage and confirms that, after exposure, the kidney participates directly in the calcium and phosphate deficiencies observed in fluoride-exposed populations.
AB - Fluoride compounds are abundant and widely distributed in the environment at a variety of concentrations. Further, fluoride induces toxic effects in target organs such as the liver and kidney. In this study, we performed an early analysis of renal function using a clearance technique in Wistar rats acutely exposed to fluoride at a plasma concentration of 0.625 μg/ml. Our results revealed that fluoride, at a concentration close to the concentration present in the serum after environmental exposure, induced a significant tubular dysfunction, resulting in diluted urine, impaired protein reabsorption, and increased calcium and phosphate urinary excretion. Our work demonstrates that even acute exposures to low concentrations of NaF may induce renal damage and confirms that, after exposure, the kidney participates directly in the calcium and phosphate deficiencies observed in fluoride-exposed populations.
KW - Acute exposure
KW - Calcium
KW - Diuresis
KW - Fluoride
KW - Kidney
KW - Phosphate
KW - Proteinuria
UR - http://www.scopus.com/inward/record.url?scp=84877874427&partnerID=8YFLogxK
U2 - 10.1007/s12011-013-9622-y
DO - 10.1007/s12011-013-9622-y
M3 - Artículo
SN - 0163-4984
VL - 152
SP - 367
EP - 372
JO - Biological Trace Element Research
JF - Biological Trace Element Research
IS - 3
ER -