TY - JOUR
T1 - Effect on risk of anencephaly of gene-nutrient interactions between methylenetetrahydrofolate reductase C677T polymorphism and maternal folate, vitamin B12 and homocysteine profile
AU - Lacasañ, Marina
AU - Blanco-Muñoz, Julia
AU - Borja-Aburto, Victor H.
AU - Aguilar-Garduño, Clemente
AU - Rodríaguez-Barranco, Miguel
AU - Sierra-Ramirez, José A.
AU - Galaviz-Hernandez, Carlos
AU - Gonzalez-Alzaga, Beatriz
AU - Garcia-Cavazos, Ricardo
PY - 2012/8
Y1 - 2012/8
N2 - Objective To evaluate the effects on anencephaly risk of the interaction between the maternal profile of folate, vitamin B12 and homocysteine and the 677C→T polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR). Design Case-control study paired (1:1) on maternity clinic, date of birth and state of residence. Cases of anencephaly were identified using the Registry of the Mexican Neural Tube Defect Epidemiological Surveillance System. Case and control mothers were selected from the same maternity departments. All mothers completed a structured questionnaire and blood samples were obtained to determine the MTHFR 677CTT polymorphism and biochemical profile. Setting Mexico, Puebla and Guerrero states, Mexico. Subjects A total of 151 mothers of cases and controls were enrolled from March 2000 to February 2001. We had complete information on biochemical profile and MTHFR C677T polymorphism for ninety-eight mothers of cases and ninety-one mothers of controls. Results The adjusted models show that the risk of anencephaly in mothers with 677TT genotype was reduced by 18 % (OR = 0.82; 95 % CI 0.72, 0.94) for each 1 ng/ml increment in serum folate. In terms of tertiles, mothers with 677TT genotype with serum folate levels in the upper tertile (>14.1 ng/ml) had a 95 % lower risk to have a child with anencephaly than mothers with serum folate levels in the first and second tertiles (P trend = 0.012). Conclusions Our data agree with the hypothesis of a gene-nutrient interaction between MTHFR 677CTT polymorphism and folate status. We observed a protective effect on anencephaly risk only in mothers with 677TT genotype as serum folate levels increased.
AB - Objective To evaluate the effects on anencephaly risk of the interaction between the maternal profile of folate, vitamin B12 and homocysteine and the 677C→T polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR). Design Case-control study paired (1:1) on maternity clinic, date of birth and state of residence. Cases of anencephaly were identified using the Registry of the Mexican Neural Tube Defect Epidemiological Surveillance System. Case and control mothers were selected from the same maternity departments. All mothers completed a structured questionnaire and blood samples were obtained to determine the MTHFR 677CTT polymorphism and biochemical profile. Setting Mexico, Puebla and Guerrero states, Mexico. Subjects A total of 151 mothers of cases and controls were enrolled from March 2000 to February 2001. We had complete information on biochemical profile and MTHFR C677T polymorphism for ninety-eight mothers of cases and ninety-one mothers of controls. Results The adjusted models show that the risk of anencephaly in mothers with 677TT genotype was reduced by 18 % (OR = 0.82; 95 % CI 0.72, 0.94) for each 1 ng/ml increment in serum folate. In terms of tertiles, mothers with 677TT genotype with serum folate levels in the upper tertile (>14.1 ng/ml) had a 95 % lower risk to have a child with anencephaly than mothers with serum folate levels in the first and second tertiles (P trend = 0.012). Conclusions Our data agree with the hypothesis of a gene-nutrient interaction between MTHFR 677CTT polymorphism and folate status. We observed a protective effect on anencephaly risk only in mothers with 677TT genotype as serum folate levels increased.
KW - Anencephaly
KW - Folate
KW - Homocysteine
KW - Methylenetetrahydrofolate reductase polymorphism
KW - Vitamin B
UR - http://www.scopus.com/inward/record.url?scp=84864042779&partnerID=8YFLogxK
U2 - 10.1017/S136898001100334X
DO - 10.1017/S136898001100334X
M3 - Artículo
C2 - 22230335
AN - SCOPUS:84864042779
SN - 1368-9800
VL - 15
SP - 1419
EP - 1428
JO - Public Health Nutrition
JF - Public Health Nutrition
IS - 8
ER -