TY - JOUR
T1 - Effect of the postsynaptic 5-HT1A receptor antagonist MM-77 on stressed mice treated with 5-HT1A receptor agents
AU - Alfredo, Briones Aranda
AU - Ofir, Picazo
N1 - Funding Information:
This study was carried out with financial support from CEGEPI-IPN (2003-567) and COFAA. A B-A received a fellowship from CONACYT.
PY - 2005/1/31
Y1 - 2005/1/31
N2 - The pharmacological effect of the 5-HT1A receptor ligands, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), indorenate, and buspirone, alone or in combination with the antagonist MM-77, was studied in mice subjected to forced swimming. It was confirmed that this stressful factor produces an anxiolytic-like effect, which is reversed by the mentioned 5-HT1A receptor agonists. Only the 8-OH-DPAT-induced decrease of such an effect could be blocked by the postsynaptic antagonist of the 5-HT1A receptor 1-(2-methoxyphenyl)-4-[(4-succinimido)butyl]-piperazine (MM-77). Stressing by forced swimming seems to induce plastic changes in 5-HT1A receptors, which in turn modify the behavioural actions of 5-HT1A receptor agents.
AB - The pharmacological effect of the 5-HT1A receptor ligands, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), indorenate, and buspirone, alone or in combination with the antagonist MM-77, was studied in mice subjected to forced swimming. It was confirmed that this stressful factor produces an anxiolytic-like effect, which is reversed by the mentioned 5-HT1A receptor agonists. Only the 8-OH-DPAT-induced decrease of such an effect could be blocked by the postsynaptic antagonist of the 5-HT1A receptor 1-(2-methoxyphenyl)-4-[(4-succinimido)butyl]-piperazine (MM-77). Stressing by forced swimming seems to induce plastic changes in 5-HT1A receptors, which in turn modify the behavioural actions of 5-HT1A receptor agents.
KW - (Mouse)
KW - 5-HT receptor
KW - Anxiety
KW - MM-77
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=12844255240&partnerID=8YFLogxK
U2 - 10.1016/j.ejphar.2004.12.013
DO - 10.1016/j.ejphar.2004.12.013
M3 - Artículo
C2 - 15680266
SN - 0014-2999
VL - 508
SP - 155
EP - 158
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1-3
ER -