Effect of omega-3 fatty acids supplementation combined with lifestyle intervention on adipokines and biomarkers of endothelial dysfunction in obese adolescents with hypertriglyceridemia

Fengyang Huang, Blanca Estela del-Río-Navarro, José Leija-Martinez, Saúl Torres-Alcantara, Eliseo Ruiz-Bedolla, Leticia Hernández-Cadena, Albino Barraza-Villarreal, Rodrigo Romero-Nava, Fausto Sanchéz-Muñoz, Santiago Villafaña, Laurence A. Marchat, Enrique Hong

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Abstract

© 2018 Elsevier Inc. Obesity in adolescents is considered a major public health problem; combined interventional approaches such as omega-3 supplementation with lifestyle intervention (LI) might exert synergistic effects and exceed the impact of each individual strategy. The purpose of the present study was to evaluate if the supplementation of omega-3 with LI could improve metabolic and endothelial abnormality in obese adolescents with hypertriglyceridemia. The study involved sixty-nine adolescents with normal weight and seventy obese adolescents with hypertriglyceridemia. All obese adolescents were applied to LI and randomly assigned to omega-3 supplementation or placebo group for 12 weeks. The obese adolescents with hypertriglyceridemia presented increased levels of leptin, retinol binding protein 4 (RBP4), selectin E (sE) and asymmetric dimethylarginine (ADMA) and decreased levels of adiponectin compared with control subjects. After 12-week intervention, omega-3 supplementation with LI decreased significantly in triglycerides, HOMA, leptin, RBP4, ADMA and sE. Moreover, omega-3 with LI displayed a significant reduction in triglycerides, ADMA and sE in comparison with LI alone. In subjects with omega-3 combined with LI assessed by multivariate regression model, the reduction in triglycerides was the only independent determinant of the decrease in ADMA. The reductions in triglycerides and HOMA were significantly contributed to the changes in sE. Our data indicated that omega-3 combined with LI in short duration significantly improved dyslipidemia, insulin resistance, abnormality of adipokines, endothelial dysfunction in comparison of LI alone, indicating the combined approach is an effective clinical and applicable strategy to control metabolic abnormality and decrease the risks of cardiovascular diseases in obese adolescents.
Original languageAmerican English
Pages (from-to)162-169
Number of pages145
JournalJournal of Nutritional Biochemistry
DOIs
StatePublished - 1 Feb 2019

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Adipokines
E-Selectin
Hypertriglyceridemia
Omega-3 Fatty Acids
Biomarkers
Life Style
Triglycerides
Retinol-Binding Proteins
Leptin
Leptin Receptors
Adiponectin
Public health
Medical problems
Insulin
N,N-dimethylarginine
Pediatric Obesity
Dyslipidemias
Insulin Resistance
Cardiovascular Diseases
Public Health

Cite this

Huang, Fengyang ; del-Río-Navarro, Blanca Estela ; Leija-Martinez, José ; Torres-Alcantara, Saúl ; Ruiz-Bedolla, Eliseo ; Hernández-Cadena, Leticia ; Barraza-Villarreal, Albino ; Romero-Nava, Rodrigo ; Sanchéz-Muñoz, Fausto ; Villafaña, Santiago ; Marchat, Laurence A. ; Hong, Enrique. / Effect of omega-3 fatty acids supplementation combined with lifestyle intervention on adipokines and biomarkers of endothelial dysfunction in obese adolescents with hypertriglyceridemia. In: Journal of Nutritional Biochemistry. 2019 ; pp. 162-169.
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abstract = "{\circledC} 2018 Elsevier Inc. Obesity in adolescents is considered a major public health problem; combined interventional approaches such as omega-3 supplementation with lifestyle intervention (LI) might exert synergistic effects and exceed the impact of each individual strategy. The purpose of the present study was to evaluate if the supplementation of omega-3 with LI could improve metabolic and endothelial abnormality in obese adolescents with hypertriglyceridemia. The study involved sixty-nine adolescents with normal weight and seventy obese adolescents with hypertriglyceridemia. All obese adolescents were applied to LI and randomly assigned to omega-3 supplementation or placebo group for 12 weeks. The obese adolescents with hypertriglyceridemia presented increased levels of leptin, retinol binding protein 4 (RBP4), selectin E (sE) and asymmetric dimethylarginine (ADMA) and decreased levels of adiponectin compared with control subjects. After 12-week intervention, omega-3 supplementation with LI decreased significantly in triglycerides, HOMA, leptin, RBP4, ADMA and sE. Moreover, omega-3 with LI displayed a significant reduction in triglycerides, ADMA and sE in comparison with LI alone. In subjects with omega-3 combined with LI assessed by multivariate regression model, the reduction in triglycerides was the only independent determinant of the decrease in ADMA. The reductions in triglycerides and HOMA were significantly contributed to the changes in sE. Our data indicated that omega-3 combined with LI in short duration significantly improved dyslipidemia, insulin resistance, abnormality of adipokines, endothelial dysfunction in comparison of LI alone, indicating the combined approach is an effective clinical and applicable strategy to control metabolic abnormality and decrease the risks of cardiovascular diseases in obese adolescents.",
author = "Fengyang Huang and del-R{\'i}o-Navarro, {Blanca Estela} and Jos{\'e} Leija-Martinez and Sa{\'u}l Torres-Alcantara and Eliseo Ruiz-Bedolla and Leticia Hern{\'a}ndez-Cadena and Albino Barraza-Villarreal and Rodrigo Romero-Nava and Fausto Sanch{\'e}z-Mu{\~n}oz and Santiago Villafa{\~n}a and Marchat, {Laurence A.} and Enrique Hong",
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Huang, F, del-Río-Navarro, BE, Leija-Martinez, J, Torres-Alcantara, S, Ruiz-Bedolla, E, Hernández-Cadena, L, Barraza-Villarreal, A, Romero-Nava, R, Sanchéz-Muñoz, F, Villafaña, S, Marchat, LA & Hong, E 2019, 'Effect of omega-3 fatty acids supplementation combined with lifestyle intervention on adipokines and biomarkers of endothelial dysfunction in obese adolescents with hypertriglyceridemia', Journal of Nutritional Biochemistry, pp. 162-169. https://doi.org/10.1016/j.jnutbio.2018.10.012

Effect of omega-3 fatty acids supplementation combined with lifestyle intervention on adipokines and biomarkers of endothelial dysfunction in obese adolescents with hypertriglyceridemia. / Huang, Fengyang; del-Río-Navarro, Blanca Estela; Leija-Martinez, José; Torres-Alcantara, Saúl; Ruiz-Bedolla, Eliseo; Hernández-Cadena, Leticia; Barraza-Villarreal, Albino; Romero-Nava, Rodrigo; Sanchéz-Muñoz, Fausto; Villafaña, Santiago; Marchat, Laurence A.; Hong, Enrique.

In: Journal of Nutritional Biochemistry, 01.02.2019, p. 162-169.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Effect of omega-3 fatty acids supplementation combined with lifestyle intervention on adipokines and biomarkers of endothelial dysfunction in obese adolescents with hypertriglyceridemia

AU - Huang, Fengyang

AU - del-Río-Navarro, Blanca Estela

AU - Leija-Martinez, José

AU - Torres-Alcantara, Saúl

AU - Ruiz-Bedolla, Eliseo

AU - Hernández-Cadena, Leticia

AU - Barraza-Villarreal, Albino

AU - Romero-Nava, Rodrigo

AU - Sanchéz-Muñoz, Fausto

AU - Villafaña, Santiago

AU - Marchat, Laurence A.

AU - Hong, Enrique

PY - 2019/2/1

Y1 - 2019/2/1

N2 - © 2018 Elsevier Inc. Obesity in adolescents is considered a major public health problem; combined interventional approaches such as omega-3 supplementation with lifestyle intervention (LI) might exert synergistic effects and exceed the impact of each individual strategy. The purpose of the present study was to evaluate if the supplementation of omega-3 with LI could improve metabolic and endothelial abnormality in obese adolescents with hypertriglyceridemia. The study involved sixty-nine adolescents with normal weight and seventy obese adolescents with hypertriglyceridemia. All obese adolescents were applied to LI and randomly assigned to omega-3 supplementation or placebo group for 12 weeks. The obese adolescents with hypertriglyceridemia presented increased levels of leptin, retinol binding protein 4 (RBP4), selectin E (sE) and asymmetric dimethylarginine (ADMA) and decreased levels of adiponectin compared with control subjects. After 12-week intervention, omega-3 supplementation with LI decreased significantly in triglycerides, HOMA, leptin, RBP4, ADMA and sE. Moreover, omega-3 with LI displayed a significant reduction in triglycerides, ADMA and sE in comparison with LI alone. In subjects with omega-3 combined with LI assessed by multivariate regression model, the reduction in triglycerides was the only independent determinant of the decrease in ADMA. The reductions in triglycerides and HOMA were significantly contributed to the changes in sE. Our data indicated that omega-3 combined with LI in short duration significantly improved dyslipidemia, insulin resistance, abnormality of adipokines, endothelial dysfunction in comparison of LI alone, indicating the combined approach is an effective clinical and applicable strategy to control metabolic abnormality and decrease the risks of cardiovascular diseases in obese adolescents.

AB - © 2018 Elsevier Inc. Obesity in adolescents is considered a major public health problem; combined interventional approaches such as omega-3 supplementation with lifestyle intervention (LI) might exert synergistic effects and exceed the impact of each individual strategy. The purpose of the present study was to evaluate if the supplementation of omega-3 with LI could improve metabolic and endothelial abnormality in obese adolescents with hypertriglyceridemia. The study involved sixty-nine adolescents with normal weight and seventy obese adolescents with hypertriglyceridemia. All obese adolescents were applied to LI and randomly assigned to omega-3 supplementation or placebo group for 12 weeks. The obese adolescents with hypertriglyceridemia presented increased levels of leptin, retinol binding protein 4 (RBP4), selectin E (sE) and asymmetric dimethylarginine (ADMA) and decreased levels of adiponectin compared with control subjects. After 12-week intervention, omega-3 supplementation with LI decreased significantly in triglycerides, HOMA, leptin, RBP4, ADMA and sE. Moreover, omega-3 with LI displayed a significant reduction in triglycerides, ADMA and sE in comparison with LI alone. In subjects with omega-3 combined with LI assessed by multivariate regression model, the reduction in triglycerides was the only independent determinant of the decrease in ADMA. The reductions in triglycerides and HOMA were significantly contributed to the changes in sE. Our data indicated that omega-3 combined with LI in short duration significantly improved dyslipidemia, insulin resistance, abnormality of adipokines, endothelial dysfunction in comparison of LI alone, indicating the combined approach is an effective clinical and applicable strategy to control metabolic abnormality and decrease the risks of cardiovascular diseases in obese adolescents.

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