TY - JOUR
T1 - Effect of losartan on vascular function in fructose-fed rats
T2 - The role of perivascular adipose tissue
AU - Huang, Fengyang
AU - Lezama, Miguel Angel Rosas
AU - Ontiveros, José Alfredo Pérez
AU - Bravo, Guadalupe
AU - Villafaña, Santiago
AU - Del-Rio-Navarro, Blanca Estela
AU - Hong, Enrique
N1 - Funding Information:
This research was supported by grant HIM/2006/040 from Hospital Infantíl de México Federico Gómez. The authors thank Guadalupe Gazcón Morales and Gerardo Rivera for their technical assistance.
PY - 2010/4
Y1 - 2010/4
N2 - Recent studies have shown the effect of perivascular adipose tissue (PVAT) on the regulation of vascular function; however, its role in the model of metabolic syndrome remains unclear. The aim of this study was to examine the effect of losartan on PVAT-derived vascular dysfunction in fructose-induced hypertensive rats. Rats were fed with either water, 10% fructose, or 10% fructose with 10mg/kg losartan for 8 weeks. In the isolated aorta with PVAT and endothelium, contraction induced by norepinephrine (NE) was more potent in fructose-fed rats compared to control rats. Losartan normalized blood pressure, insulin resistance, and NE-induced vasoconstriction in fructose-fed rats. In the aortic rings withwithout endothelium and with/without PVAT, losartan could not improve the acetylcholine-induced relaxation in fructose-fed rats. The observation suggested that losartan partly improved the PVAT-associated vascular regulation in fructose-induced hypertensive rats.
AB - Recent studies have shown the effect of perivascular adipose tissue (PVAT) on the regulation of vascular function; however, its role in the model of metabolic syndrome remains unclear. The aim of this study was to examine the effect of losartan on PVAT-derived vascular dysfunction in fructose-induced hypertensive rats. Rats were fed with either water, 10% fructose, or 10% fructose with 10mg/kg losartan for 8 weeks. In the isolated aorta with PVAT and endothelium, contraction induced by norepinephrine (NE) was more potent in fructose-fed rats compared to control rats. Losartan normalized blood pressure, insulin resistance, and NE-induced vasoconstriction in fructose-fed rats. In the aortic rings withwithout endothelium and with/without PVAT, losartan could not improve the acetylcholine-induced relaxation in fructose-fed rats. The observation suggested that losartan partly improved the PVAT-associated vascular regulation in fructose-induced hypertensive rats.
KW - Fructose
KW - Hypertension
KW - Losartan
KW - Perivascular adipose tissue
KW - Vascular function
UR - http://www.scopus.com/inward/record.url?scp=77950842909&partnerID=8YFLogxK
U2 - 10.3109/10641960902993129
DO - 10.3109/10641960902993129
M3 - Artículo
SN - 1064-1963
VL - 32
SP - 98
EP - 104
JO - Clinical and Experimental Hypertension
JF - Clinical and Experimental Hypertension
IS - 2
ER -