TY - JOUR
T1 - Effect of ibuprofen exposure on blood, gill, liver, and brain on common carp (Cyprinus carpio) using oxidative stress biomarkers
AU - Islas-Flores, Hariz
AU - Gómez-Oliván, Leobardo Manuel
AU - Galar-Martínez, Marcela
AU - García-Medina, Sandra
AU - Neri-Cruz, Nadia
AU - Dublán-García, Octavio
N1 - Funding Information:
Acknowledgments This study was made possible through support from the Consejo Nacional de Ciencia y Tecnología (CONACyT-Mexico, project 151665) and the Secretaria de Investigación y Estudios Avanzados de la UAEM (SIEA-UAEM, project UAEM 3415/2013CHT).
PY - 2014/4
Y1 - 2014/4
N2 - Although trace concentrations of ibuprofen (IBP) have been detected in diverse water bodies, there is currently insufficient information on the potentially deleterious effects of this xenobiotic. The present study aimed to determine whether IBP induces oxidative stress in brain, liver, gill, and blood of the common carp Cyprinus carpio. To this end, the median lethal concentration at 96 h (96-h LC50) was determined and the lowest observed adverse effect level was established. Carp were exposed to the latter concentration (17.6 mg L-1) for 12, 24, 48, 72, and 96 h, and the following biomarkers were evaluated: lipid peroxidation (LPX) and activity of the antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase. Results indicated that LPX and antioxidant enzymes' activity increased significantly (p < 0.05) with respect to the control group in liver, gill, and blood, while no significant differences occurred in brain. In conclusion, IBP induced oxidative stress on C. carpio, the liver being the organ most affected by this damage.
AB - Although trace concentrations of ibuprofen (IBP) have been detected in diverse water bodies, there is currently insufficient information on the potentially deleterious effects of this xenobiotic. The present study aimed to determine whether IBP induces oxidative stress in brain, liver, gill, and blood of the common carp Cyprinus carpio. To this end, the median lethal concentration at 96 h (96-h LC50) was determined and the lowest observed adverse effect level was established. Carp were exposed to the latter concentration (17.6 mg L-1) for 12, 24, 48, 72, and 96 h, and the following biomarkers were evaluated: lipid peroxidation (LPX) and activity of the antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase. Results indicated that LPX and antioxidant enzymes' activity increased significantly (p < 0.05) with respect to the control group in liver, gill, and blood, while no significant differences occurred in brain. In conclusion, IBP induced oxidative stress on C. carpio, the liver being the organ most affected by this damage.
KW - Catalase
KW - Cyprinus carpio
KW - Glutathione peroxidase
KW - Ibuprofen
KW - Lipid peroxidation
KW - Superoxide dismutase
UR - http://www.scopus.com/inward/record.url?scp=84897013755&partnerID=8YFLogxK
U2 - 10.1007/s11356-013-2477-0
DO - 10.1007/s11356-013-2477-0
M3 - Artículo
SN - 0944-1344
VL - 21
SP - 5157
EP - 5166
JO - Environmental Science and Pollution Research
JF - Environmental Science and Pollution Research
IS - 7
ER -