TY - JOUR
T1 - Effect of hyperbaric oxygenation in total antioxidant system, nitric oxide and 3 nitrotyrosine levels in a rat model of acute myocardial infarct in the absence of reperfusion
AU - Guadalupe, Navarro Barrientos María
AU - del Carmen, Castillo Hernández María
AU - Alexandre, Kormanovski
AU - Eleazar, Lara Padilla
AU - Pimentel-Montejano, Victor Hugo
AU - Olaf, Gonzalez Villegas
AU - Lopez-Mayorga, Ruth Mery
AU - Gustavo, Guevara Balcazar
N1 - Publisher Copyright:
© 2015 Asian Network for Scientific Information.
PY - 2015/8/28
Y1 - 2015/8/28
N2 - Coronary heart disease is one of the main causes of death worldwide. Only 10-15% of patients in Mexico receive the standard treatment (reperfusion therapy) leaving the vast majority without an effective remedy. One possible coadjuvant treatment after acute myocardial infarction is Hyperbaric Oxygen Therapy (HBO), which has shown beneficial effects in patients having pathologies with an ischemic origin. The HBO therapy is known to favor vascular regeneration and oxygenation of ischemic tissues and to stimulate an increase in antioxidant enzymes in tissues and plasma. The aim of this study was to evaluate the levels of enzymes of the antioxidant system and oxidative status in a rat model of Acute Myocardial Infarct (AMI) with HBO therapy. The anterior descending artery was surgically ligated to provoke AMI, Rats were grouped: without HBO and with HBO treatment (for 1, 3, 5, 10 or 20 sessions with 100% oxygen at 2 atmospheres for 60 min). After sacrifice, the heart was extracted to evaluate the left and right side for Total Antioxidant Response (TAS) and levels of nitric oxide and 3’nitrotyrosine. Left heart samples were taken from the ischemic area. In the left heart, the HBO therapy group had a higher level of 3’nitrotyrosine (compared to basal values) in the ischemic area at the 20th session. This indicates a greater production of NO, favoring better recovery in the ischemic area, improvement in the penumbra area and greater vascularization.
AB - Coronary heart disease is one of the main causes of death worldwide. Only 10-15% of patients in Mexico receive the standard treatment (reperfusion therapy) leaving the vast majority without an effective remedy. One possible coadjuvant treatment after acute myocardial infarction is Hyperbaric Oxygen Therapy (HBO), which has shown beneficial effects in patients having pathologies with an ischemic origin. The HBO therapy is known to favor vascular regeneration and oxygenation of ischemic tissues and to stimulate an increase in antioxidant enzymes in tissues and plasma. The aim of this study was to evaluate the levels of enzymes of the antioxidant system and oxidative status in a rat model of Acute Myocardial Infarct (AMI) with HBO therapy. The anterior descending artery was surgically ligated to provoke AMI, Rats were grouped: without HBO and with HBO treatment (for 1, 3, 5, 10 or 20 sessions with 100% oxygen at 2 atmospheres for 60 min). After sacrifice, the heart was extracted to evaluate the left and right side for Total Antioxidant Response (TAS) and levels of nitric oxide and 3’nitrotyrosine. Left heart samples were taken from the ischemic area. In the left heart, the HBO therapy group had a higher level of 3’nitrotyrosine (compared to basal values) in the ischemic area at the 20th session. This indicates a greater production of NO, favoring better recovery in the ischemic area, improvement in the penumbra area and greater vascularization.
KW - Hyperbaric oxygenation
KW - Ischemic heart
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=84942090658&partnerID=8YFLogxK
U2 - 10.3923/ijp.2015.834.839
DO - 10.3923/ijp.2015.834.839
M3 - Artículo
SN - 1811-7775
VL - 11
SP - 834
EP - 839
JO - International Journal of Pharmacology
JF - International Journal of Pharmacology
IS - 7
ER -