TY - JOUR
T1 - Effect of fructooligosaccharides fraction from Psacalium decompositum on inflammation and dyslipidemia in rats with fructose-induced obesity
AU - Merino-Aguilar, Héctor
AU - Arrieta-Baez, Daniel
AU - Jiménez-Estrada, Manuel
AU - Magos-Guerrero, Gil
AU - Hernández-Bautista, René Javier
AU - Susunaga-Notario, Ana del Carmen
AU - Almanza-Pérez, Julio Cesar
AU - Blancas-Flores, Gerardo
AU - Román-Ramos, Rubén
AU - Alarcón-Aguilar, Francisco Javier
PY - 2014/1/29
Y1 - 2014/1/29
N2 - Psacalium decompositum, commonly known as "Matarique," is a medicinal plant used in Mexico for diabetes mellitus empirical therapy. Previous studies have shown that the fructooligosaccharides (FOS) present in the roots of this plant exhibit a notable hypoglycemic effect in animal models; this effect might be associated with the attenuation of the inflammatory process and other metabolic disorders. In this study, we examined theeffects of FOS fraction administration in a fructose-fed rat model for obesity. Phytochemical chromatographic studies (high performance thin layer chromatography and nuclear magnetic resonance) were performed to verify isolation of FOS. 24 male Wistar rats were maintained for 12 weeks on a diet of 20% HFCS in drinking water and chow. Glucose, cholesterol, triglycerides and liver transaminases levels were measured monthly, after administering FOS fraction intragastrically (150 mg/kg/day for 12 weeks), while the levels of inflammatory cytokines were only quantified at the end of the treatments. Rats treated with FOS fraction decreased body weight, cholesterol, triglycerides, and significantly reduced IL-6, IFN-γ, MCP-1, IL-1β and VEGF levels (p < 0.05). These results suggest that P. decompositum has anti-inflammatory and hypolipidemic properties that might be used as an alternative treatment for the control of obesity.
AB - Psacalium decompositum, commonly known as "Matarique," is a medicinal plant used in Mexico for diabetes mellitus empirical therapy. Previous studies have shown that the fructooligosaccharides (FOS) present in the roots of this plant exhibit a notable hypoglycemic effect in animal models; this effect might be associated with the attenuation of the inflammatory process and other metabolic disorders. In this study, we examined theeffects of FOS fraction administration in a fructose-fed rat model for obesity. Phytochemical chromatographic studies (high performance thin layer chromatography and nuclear magnetic resonance) were performed to verify isolation of FOS. 24 male Wistar rats were maintained for 12 weeks on a diet of 20% HFCS in drinking water and chow. Glucose, cholesterol, triglycerides and liver transaminases levels were measured monthly, after administering FOS fraction intragastrically (150 mg/kg/day for 12 weeks), while the levels of inflammatory cytokines were only quantified at the end of the treatments. Rats treated with FOS fraction decreased body weight, cholesterol, triglycerides, and significantly reduced IL-6, IFN-γ, MCP-1, IL-1β and VEGF levels (p < 0.05). These results suggest that P. decompositum has anti-inflammatory and hypolipidemic properties that might be used as an alternative treatment for the control of obesity.
KW - Asteraceae
KW - Dyslipidemia
KW - Fructose
KW - Inflammatory cytokines
KW - Obesity
KW - Psacalium decompositum
UR - http://www.scopus.com/inward/record.url?scp=84893259111&partnerID=8YFLogxK
U2 - 10.3390/nu6020591
DO - 10.3390/nu6020591
M3 - Artículo
SN - 2072-6643
VL - 6
SP - 591
EP - 604
JO - Nutrients
JF - Nutrients
IS - 2
ER -