Effect of excitotoxic lesions of the neonatal ventral hippocampus on the immobility response in rats

Gonzalo Flores, Adriana B. Silva-Gómez, David Barbeau, Lalit K. Srivastava, Sergio Zamudio, Fidel De La Cruz López

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Rats with neonatal ventral hippocampal (nVH) lesions show postpubertal hypersensitivity to dopamine agonists, which may be reversed by neuroleptic treatment. In addition, the immobility response (IR) may be regulated by dopaminergic activity. We investigated the influence of the IR caused by clamping the neck of rats that had received bilateral ibotenic acid lesions of the ventral hippocampus at postnatal day 7 (PD7). At both ages, prepubertal (PD35) and postpubertal (PD56), the duration of the IR was significantly increased in animals with lesions when compared to controls. These findings indicate that nVH damage results in behavioral changes, such as enhancement of the IR, related to mesolimbic dopaminergic transmission. © 2005 Elsevier Inc. All rights reserved.
Original languageAmerican English
Pages (from-to)2339-2348
Number of pages2104
JournalLife Sciences
DOIs
StatePublished - 1 Apr 2005

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Rats
Hippocampus
Ibotenic Acid
Dopamine Agonists
Constriction
Antipsychotic Agents
Hypersensitivity
Animals
Neck

Cite this

Flores, Gonzalo ; Silva-Gómez, Adriana B. ; Barbeau, David ; Srivastava, Lalit K. ; Zamudio, Sergio ; De La Cruz López, Fidel. / Effect of excitotoxic lesions of the neonatal ventral hippocampus on the immobility response in rats. In: Life Sciences. 2005 ; pp. 2339-2348.
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Effect of excitotoxic lesions of the neonatal ventral hippocampus on the immobility response in rats. / Flores, Gonzalo; Silva-Gómez, Adriana B.; Barbeau, David; Srivastava, Lalit K.; Zamudio, Sergio; De La Cruz López, Fidel.

In: Life Sciences, 01.04.2005, p. 2339-2348.

Research output: Contribution to journalArticle

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