TY - JOUR
T1 - Effect of excitotoxic lesions of the neonatal ventral hippocampus on the immobility response in rats
AU - Flores, Gonzalo
AU - Silva-Gómez, Adriana B.
AU - Barbeau, David
AU - Srivastava, Lalit K.
AU - Zamudio, Sergio
AU - De La Cruz López, Fidel
N1 - Funding Information:
This study was supported in part by grants from CONACyT-Mexico (No. 40664-M) and Fundación Mexicana para la Salud AC. We are grateful to Dr. Carlos Escamilla for his help and suggestions related to the keeping of animals and to Dr. Ellis Glazier for the editing of the English-language text. GF and SZ are members of the Researcher National System of Mexico. FD and SZ are fellows of DEDICT-COFAA-IPN. LKS is Chercheur-boursier and Chercheur-boursier de mérite exceptionel of the FRSQ.
PY - 2005/4/1
Y1 - 2005/4/1
N2 - Rats with neonatal ventral hippocampal (nVH) lesions show postpubertal hypersensitivity to dopamine agonists, which may be reversed by neuroleptic treatment. In addition, the immobility response (IR) may be regulated by dopaminergic activity. We investigated the influence of the IR caused by clamping the neck of rats that had received bilateral ibotenic acid lesions of the ventral hippocampus at postnatal day 7 (PD7). At both ages, prepubertal (PD35) and postpubertal (PD56), the duration of the IR was significantly increased in animals with lesions when compared to controls. These findings indicate that nVH damage results in behavioral changes, such as enhancement of the IR, related to mesolimbic dopaminergic transmission.
AB - Rats with neonatal ventral hippocampal (nVH) lesions show postpubertal hypersensitivity to dopamine agonists, which may be reversed by neuroleptic treatment. In addition, the immobility response (IR) may be regulated by dopaminergic activity. We investigated the influence of the IR caused by clamping the neck of rats that had received bilateral ibotenic acid lesions of the ventral hippocampus at postnatal day 7 (PD7). At both ages, prepubertal (PD35) and postpubertal (PD56), the duration of the IR was significantly increased in animals with lesions when compared to controls. These findings indicate that nVH damage results in behavioral changes, such as enhancement of the IR, related to mesolimbic dopaminergic transmission.
KW - Behavior
KW - Immobility response
KW - Neonatal ventral hippocampus lesion
KW - Neurodevelopmental
UR - http://www.scopus.com/inward/record.url?scp=14644425441&partnerID=8YFLogxK
U2 - 10.1016/j.lfs.2004.11.007
DO - 10.1016/j.lfs.2004.11.007
M3 - Artículo
SN - 0024-3205
VL - 76
SP - 2339
EP - 2348
JO - Life Sciences
JF - Life Sciences
IS - 20
ER -