Hepatoprotective and antioxidant e!ects of Taraxacum officinale against carbon tetrachloride induced acute hepatic damage in the rat

Liliana Favari; Carlos Arce-Díaz; Julieta Ortíz-Martínez; Saudy Pablo-Pérez; Claudia Soto; María Estela Meléndez-Camargo

Hepatoprotective and antioxidant e!ects of Taraxacum officinale against carbon tetrachloride induced acute hepatic damage in the rat

Translated title of the contribution: Hepatoprotective and antioxidant e!ects of Taraxacum officinale against carbon tetrachloride induced acute hepatic damage in the rat

Liliana Favari, Carlos Arce-Díaz, Julieta Ortíz-Martínez, Saudy Pablo-Pérez, Claudia Soto, María Estela Meléndez-Camargo

Escuela Nacional de Ciencias Biológicas (ENCB)

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The purpose of this study was to evaluate the hepatoprotective and antioxidant e!ects of Taraxacum offcinale (100, 200 and 400 mg/kg) in the acute liver intoxication with carbon tetrachloride (CCl₄) in rats that were protected with T. offcinale and colchicine (positive control) orally for three days started three hours after the CCl₄ administration. The aqueous extract of T. offcinale decreased the elevated hepatic activities of alanine aminotransferase, alkaline phosphatase and gamma glutamyltranspeptidase, serum bilirubin and lipid peroxidation and elevated catalase and glutathione peroxidasa. The extract presented high total phenolic compound content and moderate DPPH. scavenging activity. Taraxacum o!cinale possessed hepatoprotective and antioxidant effects that evidenced the traditional use of this plant.

Translated title of the contribution	Hepatoprotective and antioxidant e!ects of Taraxacum officinale against carbon tetrachloride induced acute hepatic damage in the rat
Original language	English
Pages (from-to)	53-61
Number of pages	9
Journal	Revista Mexicana de Ciencias Farmaceuticas
Volume	44
Issue number	4
State	Published - 2013

Keywords

Dandelion
Liver biomarkers
T. Offcinale
Total plenolic compounds

Cite this

@article{f008678ee11a447baf0416bf2af0d387,

title = "Hepatoprotective and antioxidant e!ects of Taraxacum officinale against carbon tetrachloride induced acute hepatic damage in the rat",

abstract = "The purpose of this study was to evaluate the hepatoprotective and antioxidant e!ects of Taraxacum offcinale (100, 200 and 400 mg/kg) in the acute liver intoxication with carbon tetrachloride (CCl4) in rats that were protected with T. offcinale and colchicine (positive control) orally for three days started three hours after the CCl4 administration. The aqueous extract of T. offcinale decreased the elevated hepatic activities of alanine aminotransferase, alkaline phosphatase and gamma glutamyltranspeptidase, serum bilirubin and lipid peroxidation and elevated catalase and glutathione peroxidasa. The extract presented high total phenolic compound content and moderate DPPH. scavenging activity. Taraxacum o!cinale possessed hepatoprotective and antioxidant effects that evidenced the traditional use of this plant.",

keywords = "Dandelion, Liver biomarkers, T. Offcinale, Total plenolic compounds",

author = "Liliana Favari and Carlos Arce-D{\'i}az and Julieta Ort{\'i}z-Mart{\'i}nez and Saudy Pablo-P{\'e}rez and Claudia Soto and Mel{\'e}ndez-Camargo, {Mar{\'i}a Estela}",

year = "2013",

language = "Ingl{\'e}s",

volume = "44",

pages = "53--61",

journal = "Revista Mexicana de Ciencias Farmaceuticas",

issn = "1027-3956",

number = "4",

}

TY - JOUR

T1 - Hepatoprotective and antioxidant e!ects of Taraxacum officinale against carbon tetrachloride induced acute hepatic damage in the rat

AU - Favari, Liliana

AU - Arce-Díaz, Carlos

AU - Ortíz-Martínez, Julieta

AU - Pablo-Pérez, Saudy

AU - Soto, Claudia

AU - Meléndez-Camargo, María Estela

PY - 2013

Y1 - 2013

N2 - The purpose of this study was to evaluate the hepatoprotective and antioxidant e!ects of Taraxacum offcinale (100, 200 and 400 mg/kg) in the acute liver intoxication with carbon tetrachloride (CCl4) in rats that were protected with T. offcinale and colchicine (positive control) orally for three days started three hours after the CCl4 administration. The aqueous extract of T. offcinale decreased the elevated hepatic activities of alanine aminotransferase, alkaline phosphatase and gamma glutamyltranspeptidase, serum bilirubin and lipid peroxidation and elevated catalase and glutathione peroxidasa. The extract presented high total phenolic compound content and moderate DPPH. scavenging activity. Taraxacum o!cinale possessed hepatoprotective and antioxidant effects that evidenced the traditional use of this plant.

AB - The purpose of this study was to evaluate the hepatoprotective and antioxidant e!ects of Taraxacum offcinale (100, 200 and 400 mg/kg) in the acute liver intoxication with carbon tetrachloride (CCl4) in rats that were protected with T. offcinale and colchicine (positive control) orally for three days started three hours after the CCl4 administration. The aqueous extract of T. offcinale decreased the elevated hepatic activities of alanine aminotransferase, alkaline phosphatase and gamma glutamyltranspeptidase, serum bilirubin and lipid peroxidation and elevated catalase and glutathione peroxidasa. The extract presented high total phenolic compound content and moderate DPPH. scavenging activity. Taraxacum o!cinale possessed hepatoprotective and antioxidant effects that evidenced the traditional use of this plant.

KW - Dandelion

KW - Liver biomarkers

KW - T. Offcinale

KW - Total plenolic compounds

UR - http://www.scopus.com/inward/record.url?scp=84903640325&partnerID=8YFLogxK

M3 - Artículo

SN - 1027-3956

VL - 44

SP - 53

EP - 61

JO - Revista Mexicana de Ciencias Farmaceuticas

JF - Revista Mexicana de Ciencias Farmaceuticas

IS - 4

ER -

Hepatoprotective and antioxidant e!ects of Taraxacum officinale against carbon tetrachloride induced acute hepatic damage in the rat

Abstract

Keywords

Other files and links

Fingerprint

Cite this