TY - JOUR
T1 - Efecto de la administración subcrónica de glucosamina oral en la regulación del peso corporal, glucemia y dislipidemias provocada por una dieta hipercalórica en rata Wistar
AU - Barrientos Alvarado, Cornelio
AU - Sánchez Vázquez, Jorge
AU - Cárdenas Oscoy, María Atanasia Silvia
AU - Garrido Acosta, Osvaldo
AU - Anguiano Robledo, Osvaldo
PY - 2014
Y1 - 2014
N2 - Objective: This study evaluated the effect of oral glucosamine on overweight and dyslipidemia caused by a high-fat diet in rats. Methods: Four groups of Wistar rats: fed with commercial rodent food and drinking water without (control group) and with glucosamine (500 mg kg-1 per day) and a high-fat diet enriched with 24% (g/g) butter pork and drinking water without and with glucosamine, for 22 weeks; the body weight, abdominal fat, blood glucose, triglycerides, total cholesterol, and high density lipoprotein in serum were evaluated. Results: Body weight gain, increased blood glucose levels and dyslipidemia were observed in the high-fat diet group versus the control group (p<0.001). When glucosamine was administered the same diet the effects were minimized, with a decrease in the amount of abdominal-fat and lipid profile levels in serum (p>0.05), regulated body weight, and high density lipoprotein and glycaemia (p<0.05). The glucosamine did not affect body weight and lipid metabolism in rats when administered with a normal diet. Conclusions: Glucosamine regulated the body weight blood glucose and dyslipidemia caused by a high-fat diet, favoring increased high density lipoprotein cholesterol in rats. It did not affect body weight and lipid metabolism when administered with commercial food.
AB - Objective: This study evaluated the effect of oral glucosamine on overweight and dyslipidemia caused by a high-fat diet in rats. Methods: Four groups of Wistar rats: fed with commercial rodent food and drinking water without (control group) and with glucosamine (500 mg kg-1 per day) and a high-fat diet enriched with 24% (g/g) butter pork and drinking water without and with glucosamine, for 22 weeks; the body weight, abdominal fat, blood glucose, triglycerides, total cholesterol, and high density lipoprotein in serum were evaluated. Results: Body weight gain, increased blood glucose levels and dyslipidemia were observed in the high-fat diet group versus the control group (p<0.001). When glucosamine was administered the same diet the effects were minimized, with a decrease in the amount of abdominal-fat and lipid profile levels in serum (p>0.05), regulated body weight, and high density lipoprotein and glycaemia (p<0.05). The glucosamine did not affect body weight and lipid metabolism in rats when administered with a normal diet. Conclusions: Glucosamine regulated the body weight blood glucose and dyslipidemia caused by a high-fat diet, favoring increased high density lipoprotein cholesterol in rats. It did not affect body weight and lipid metabolism when administered with commercial food.
KW - Blood glucose
KW - Body weight
KW - Cholesterol
KW - Glucosamine
KW - HDL
UR - http://www.scopus.com/inward/record.url?scp=84921879782&partnerID=8YFLogxK
U2 - 10.1590/1415-52732014000600004
DO - 10.1590/1415-52732014000600004
M3 - Artículo
AN - SCOPUS:84921879782
SN - 1415-5273
VL - 27
SP - 689
EP - 701
JO - Revista de Nutricao
JF - Revista de Nutricao
IS - 6
ER -