Efecto antiinflamatorio de Pinus leiophylla Schlechtendal & Cham. en la rata

Yazmín K. Márquez F.; Sara Alvear R.; Hortensia Montellano R.; Ma Estela Meléndez Camargo

Efecto antiinflamatorio de Pinus leiophylla Schlechtendal & Cham. en la rata

Translated title of the contribution: Anti-inflammatory effect of Pinus leiophylla Schlechtendal & Cham. in the rat

Yazmín K. Márquez F., Sara Alvear R., Hortensia Montellano R., Ma Estela Meléndez Camargo

Escuela Nacional de Ciencias Biológicas (ENCB)

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

the Pinus leiophylla bark (Pinaceae) is used in Mexican Folk Medicine as an anti-inflammatory drug, therefore, it was important to evaluate this effect, on cotton pellet-induced granuloma formation in rats. Aqueous extract (74 mg/kg) and indomethacin (5 mg/kg) induced an anti-inflammatory effect, however, only indomethacin and aqueous extract reduced the granuloma dry and final weight (p<0.05). Aqueous extract (37 mg/kg) did not show any effect. Indomethacin induced an evident gastroduodenal irritation, whereas aqueous extract (74 mg/kg) induced only a slight duodenum reddening. Indomethacin and aqueous extract (74 mg/kg) decrease the inflammatory cell population.The LD₅₀ was higher than 40 g/kg. Pinus leiophylla induced an anti-inflammatory effect (74 mg/kg). Aqueous extract was non toxic.

Translated title of the contribution	Anti-inflammatory effect of Pinus leiophylla Schlechtendal & Cham. in the rat
Original language	Spanish
Pages (from-to)	22-27
Number of pages	6
Journal	Revista Mexicana de Ciencias Farmaceuticas
Volume	39
Issue number	2
State	Published - Apr 2008

Cite this

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title = "Efecto antiinflamatorio de Pinus leiophylla Schlechtendal & Cham. en la rata",

abstract = "the Pinus leiophylla bark (Pinaceae) is used in Mexican Folk Medicine as an anti-inflammatory drug, therefore, it was important to evaluate this effect, on cotton pellet-induced granuloma formation in rats. Aqueous extract (74 mg/kg) and indomethacin (5 mg/kg) induced an anti-inflammatory effect, however, only indomethacin and aqueous extract reduced the granuloma dry and final weight (p<0.05). Aqueous extract (37 mg/kg) did not show any effect. Indomethacin induced an evident gastroduodenal irritation, whereas aqueous extract (74 mg/kg) induced only a slight duodenum reddening. Indomethacin and aqueous extract (74 mg/kg) decrease the inflammatory cell population.The LD50 was higher than 40 g/kg. Pinus leiophylla induced an anti-inflammatory effect (74 mg/kg). Aqueous extract was non toxic.",

keywords = "Anti-inflammatory, Granuloma, Indomethacin, Pinus leiophylla",

author = "{M{\'a}rquez F.}, {Yazm{\'i}n K.} and {Alvear R.}, Sara and {Montellano R.}, Hortensia and {Mel{\'e}ndez Camargo}, {Ma Estela}",

year = "2008",

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journal = "Revista Mexicana de Ciencias Farmaceuticas",

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T1 - Efecto antiinflamatorio de Pinus leiophylla Schlechtendal & Cham. en la rata

AU - Márquez F., Yazmín K.

AU - Alvear R., Sara

AU - Montellano R., Hortensia

AU - Meléndez Camargo, Ma Estela

PY - 2008/4

Y1 - 2008/4

N2 - the Pinus leiophylla bark (Pinaceae) is used in Mexican Folk Medicine as an anti-inflammatory drug, therefore, it was important to evaluate this effect, on cotton pellet-induced granuloma formation in rats. Aqueous extract (74 mg/kg) and indomethacin (5 mg/kg) induced an anti-inflammatory effect, however, only indomethacin and aqueous extract reduced the granuloma dry and final weight (p<0.05). Aqueous extract (37 mg/kg) did not show any effect. Indomethacin induced an evident gastroduodenal irritation, whereas aqueous extract (74 mg/kg) induced only a slight duodenum reddening. Indomethacin and aqueous extract (74 mg/kg) decrease the inflammatory cell population.The LD50 was higher than 40 g/kg. Pinus leiophylla induced an anti-inflammatory effect (74 mg/kg). Aqueous extract was non toxic.

AB - the Pinus leiophylla bark (Pinaceae) is used in Mexican Folk Medicine as an anti-inflammatory drug, therefore, it was important to evaluate this effect, on cotton pellet-induced granuloma formation in rats. Aqueous extract (74 mg/kg) and indomethacin (5 mg/kg) induced an anti-inflammatory effect, however, only indomethacin and aqueous extract reduced the granuloma dry and final weight (p<0.05). Aqueous extract (37 mg/kg) did not show any effect. Indomethacin induced an evident gastroduodenal irritation, whereas aqueous extract (74 mg/kg) induced only a slight duodenum reddening. Indomethacin and aqueous extract (74 mg/kg) decrease the inflammatory cell population.The LD50 was higher than 40 g/kg. Pinus leiophylla induced an anti-inflammatory effect (74 mg/kg). Aqueous extract was non toxic.

KW - Anti-inflammatory

KW - Granuloma

KW - Indomethacin

KW - Pinus leiophylla

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M3 - Artículo

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SN - 1027-3956

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JO - Revista Mexicana de Ciencias Farmaceuticas

JF - Revista Mexicana de Ciencias Farmaceuticas

IS - 2

ER -

Efecto antiinflamatorio de Pinus leiophylla Schlechtendal & Cham. en la rata

Abstract

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