TY - JOUR
T1 - DNA repair mechanisms in eukaryotes
T2 - Special focus in Entamoeba histolytica and related protozoan parasites
AU - López-Camarillo, César
AU - Lopez-Casamichana, Mavil
AU - Weber, Christian
AU - Guillen, Nancy
AU - Orozco, Esther
AU - Marchat, Laurence A.
N1 - Funding Information:
This work was supported by Mexican grants from UACM, CONACyT (50845), COFAA-IPN and SIP-IPN. We thank Sollange Archer for her help in the artwork.
PY - 2009/12
Y1 - 2009/12
N2 - Eukaryotic cell viability highly relies on genome stability and DNA integrity maintenance. The cellular response to DNA damage mainly consists of six biological conserved pathways known as homologous recombination repair (HRR), non-homologous end-joining (NHEJ), base excision repair (BER), mismatch repair (MMR), nucleotide excision repair (NER), and methyltransferase repair that operate in a concerted way to minimize genetic information loss due to a DNA lesion. Particularly, protozoan parasites survival depends on DNA repair mechanisms that constantly supervise chromosomes to correct damaged nucleotides generated by cytotoxic agents, host immune pressure or cellular processes. Here we reviewed the current knowledge about DNA repair mechanisms in the most relevant human protozoan pathogens. Additionally, we described the recent advances to understand DNA repair mechanisms in Entamoeba histolytica with special emphasis in the use of genomic approaches based on bioinformatic analysis of parasite genome sequence and microarrays technology.
AB - Eukaryotic cell viability highly relies on genome stability and DNA integrity maintenance. The cellular response to DNA damage mainly consists of six biological conserved pathways known as homologous recombination repair (HRR), non-homologous end-joining (NHEJ), base excision repair (BER), mismatch repair (MMR), nucleotide excision repair (NER), and methyltransferase repair that operate in a concerted way to minimize genetic information loss due to a DNA lesion. Particularly, protozoan parasites survival depends on DNA repair mechanisms that constantly supervise chromosomes to correct damaged nucleotides generated by cytotoxic agents, host immune pressure or cellular processes. Here we reviewed the current knowledge about DNA repair mechanisms in the most relevant human protozoan pathogens. Additionally, we described the recent advances to understand DNA repair mechanisms in Entamoeba histolytica with special emphasis in the use of genomic approaches based on bioinformatic analysis of parasite genome sequence and microarrays technology.
KW - DNA damage
KW - DNA repair machineries
KW - Entamoeba histolytica
KW - Genome sequence
KW - Protozoan parasites
KW - cDNA microarrays
UR - http://www.scopus.com/inward/record.url?scp=70449561537&partnerID=8YFLogxK
U2 - 10.1016/j.meegid.2009.06.024
DO - 10.1016/j.meegid.2009.06.024
M3 - Artículo de revisión
SN - 1567-1348
VL - 9
SP - 1051
EP - 1056
JO - Infection, Genetics and Evolution
JF - Infection, Genetics and Evolution
IS - 6
ER -