TY - CHAP
T1 - DNA Alterations and Cellular Damage Induced by Non-steroidal Anti-inflammatories on Different Species of Fish
AU - SanJuan-Reyes, Nely
AU - Gómez-Oliván, Leobardo Manuel
AU - Pérez-Pastén Borja, Ricardo
AU - Islas-Flores, Hariz
AU - Galar-Martínez, Marcela
AU - García-Medina, Sandra
N1 - Publisher Copyright:
© 2020, Springer Nature Switzerland AG.
PY - 2020
Y1 - 2020
N2 - Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs used to reduce inflammation, pain, and fever by inhibiting the enzyme cyclooxygenase (COX 1 and COX 2). These drugs have been positioned among the most consumed worldwide. After their biotransformation in the body, they are eliminated as metabolites, and also in the environment they can undergo transformations, generating products that are more toxic than the original molecule. Several studies have shown that NSAIDs are not eliminated in conventional treatments used by wastewater treatment plants and represent a continuous contribution to the environment, causing significant effects on biota. However, there has been little attention given to the study of its toxic effects on aquatic organisms. The objective of this chapter is to review, compile, and analyze the oxidative damage induced by NSAIDs in different aquatic organisms, to evaluate the ecotoxicological effects of this type of drugs.
AB - Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs used to reduce inflammation, pain, and fever by inhibiting the enzyme cyclooxygenase (COX 1 and COX 2). These drugs have been positioned among the most consumed worldwide. After their biotransformation in the body, they are eliminated as metabolites, and also in the environment they can undergo transformations, generating products that are more toxic than the original molecule. Several studies have shown that NSAIDs are not eliminated in conventional treatments used by wastewater treatment plants and represent a continuous contribution to the environment, causing significant effects on biota. However, there has been little attention given to the study of its toxic effects on aquatic organisms. The objective of this chapter is to review, compile, and analyze the oxidative damage induced by NSAIDs in different aquatic organisms, to evaluate the ecotoxicological effects of this type of drugs.
KW - Aquatic species
KW - Drugs
KW - Toxic effects
UR - http://www.scopus.com/inward/record.url?scp=85093067626&partnerID=8YFLogxK
U2 - 10.1007/698_2020_544
DO - 10.1007/698_2020_544
M3 - Capítulo
AN - SCOPUS:85093067626
T3 - Handbook of Environmental Chemistry
SP - 105
EP - 114
BT - Handbook of Environmental Chemistry
PB - Springer Science and Business Media Deutschland GmbH
ER -