TY - JOUR
T1 - Diuretic effect of the aqueous extract of Bidens odorata in the rat
AU - Meléndez Camargo, Ma Estela
AU - Berdeja, Blanca
AU - Miranda, Guadalupe
N1 - Funding Information:
This work was partially supported by the Coordinación General de Posgrado e Investigación del IPN.
PY - 2004/12
Y1 - 2004/12
N2 - The aerial part of Bidens odorata Cav., are used in Mexican Folk Medicine to treat renal diseases. The aim of this study is to measure the diuretic response to aqueous extract of this plant at doses of 41 and 166 mg/kg and to compare it with that induced by furosemide at 2 mg/kg. Aqueous extracts, furosemide or vehicle were administered orally to adult rats and the effects on sodium, potassium and water balance were assessed. Aqueous extracts at both doses and furosemide produced important and significant increments in urinary excretion of sodium, potassium and water in rats with respect to control group. This increase was dose dependent and aqueous extract at the highest dose induced a more marked sodium and water excretion than furosemide, potassium excretion increased but it was less than the one induced by furosemide. These results suggest that the aqueous extract of Bidens odorata induce diuretic response.
AB - The aerial part of Bidens odorata Cav., are used in Mexican Folk Medicine to treat renal diseases. The aim of this study is to measure the diuretic response to aqueous extract of this plant at doses of 41 and 166 mg/kg and to compare it with that induced by furosemide at 2 mg/kg. Aqueous extracts, furosemide or vehicle were administered orally to adult rats and the effects on sodium, potassium and water balance were assessed. Aqueous extracts at both doses and furosemide produced important and significant increments in urinary excretion of sodium, potassium and water in rats with respect to control group. This increase was dose dependent and aqueous extract at the highest dose induced a more marked sodium and water excretion than furosemide, potassium excretion increased but it was less than the one induced by furosemide. These results suggest that the aqueous extract of Bidens odorata induce diuretic response.
KW - Bidens odorata
KW - Compositae
KW - Saluretic effect
KW - Water excretion
UR - http://www.scopus.com/inward/record.url?scp=7044272243&partnerID=8YFLogxK
U2 - 10.1016/j.jep.2004.08.005
DO - 10.1016/j.jep.2004.08.005
M3 - Artículo
C2 - 15507361
SN - 0378-8741
VL - 95
SP - 363
EP - 366
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
IS - 2-3
ER -