TY - JOUR
T1 - Disseminated penicilliosis due to Penicillium chrysogenum in a pediatric patient with Henoch–Schönlein syndrome
AU - Avilés-Robles, Martha
AU - Gómez-Ponce, Carlos
AU - Reséndiz-Sánchez, Jesús
AU - Rodríguez-Tovar, Aída Verónica
AU - Ceballos-Bocanegra, Adrián
AU - Martínez-Rivera, Ángeles
N1 - Publisher Copyright:
© 2016 The Authors
PY - 2016/10/1
Y1 - 2016/10/1
N2 - A case of disseminated infection caused by Penicillium chrysogenum in a 10-year-old boy with a history of Henoch–Schönlein purpura and proliferative glomerulonephritis, treated with immunosuppressors, is reported herein. The patient had a clinical picture of 2 weeks of fever that did not respond to treatment with broad-spectrum antibiotics and amphotericin B. Computed tomography imaging showed diffuse cotton-like infiltrates in the lungs, hepatomegaly, mesenteric lymphadenopathy, and multiple well-defined round hypodense lesions in the spleen. His treatment was changed to caspofungin, followed by voriconazole. One month later, a splenic biopsy revealed hyaline septate hyphae of > 1 μm in diameter. Fungal growth was negative. However, molecular analysis showed 99% identity with P. chrysogenum. A therapeutic splenectomy was performed, and treatment was changed to amphotericin B lipid complex and caspofungin. The patient completed 2 months of treatment with resolution of the infection. P. chrysogenum is a rare causative agent of invasive fungal infections in immunocompromised patients, and its diagnosis is necessary to initiate the appropriate antifungal treatment.
AB - A case of disseminated infection caused by Penicillium chrysogenum in a 10-year-old boy with a history of Henoch–Schönlein purpura and proliferative glomerulonephritis, treated with immunosuppressors, is reported herein. The patient had a clinical picture of 2 weeks of fever that did not respond to treatment with broad-spectrum antibiotics and amphotericin B. Computed tomography imaging showed diffuse cotton-like infiltrates in the lungs, hepatomegaly, mesenteric lymphadenopathy, and multiple well-defined round hypodense lesions in the spleen. His treatment was changed to caspofungin, followed by voriconazole. One month later, a splenic biopsy revealed hyaline septate hyphae of > 1 μm in diameter. Fungal growth was negative. However, molecular analysis showed 99% identity with P. chrysogenum. A therapeutic splenectomy was performed, and treatment was changed to amphotericin B lipid complex and caspofungin. The patient completed 2 months of treatment with resolution of the infection. P. chrysogenum is a rare causative agent of invasive fungal infections in immunocompromised patients, and its diagnosis is necessary to initiate the appropriate antifungal treatment.
KW - Disseminated penicilliosis
KW - Hyalohyphomycosis
KW - Penicilliosis
KW - Penicillium chrysogenum
UR - http://www.scopus.com/inward/record.url?scp=84988651934&partnerID=8YFLogxK
U2 - 10.1016/j.ijid.2016.08.026
DO - 10.1016/j.ijid.2016.08.026
M3 - Artículo
C2 - 27596684
SN - 1201-9712
VL - 51
SP - 78
EP - 80
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -