TY - JOUR
T1 - Diltiazem tópico en el dolor postoperatorio de hemorroidectomía con técnica cerrada
AU - Rodríguez-Wong, U.
AU - Ocharán-Hernández, M. E.
AU - Toscano-Garibay, J.
N1 - Publisher Copyright:
© 2016 Asociación Mexicana de Gastroenterología.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Background Anal sphincter spasm contributes to the appearance of postoperative pain following hemorrhoidectomy. Aim To determine the efficacy of topical diltiazem in the control of post-hemorrhoidectomy pain. Material and methods A randomized, prospective, experimental, double-blind study was conducted on 2 groups of patients in the postoperative period of closed hemorrhoidectomy. Each group consisted of 17 patients. Group A received topical diltiazem in the anal region 3 times a day and group B received a placebo. Ketorolac was administered to both groups as rescue therapy. Results In group A, the mean score on the visual analog scale was 2.97 ± 1.18 cm at 24 h, 1.51 ± 1.18 cm at 48 h, and 0.84 ± 0.92 cm at 72 h. In group B, it was 6.82 ± 1.9 cm at 24 h, 5.3 ± 1.66 cm at 48 h, and 4.32 ± 2.13 cm at 72 h (P<.001, 95% CI). The mean number of analgesic doses in group A was 2.41 ± 0.87 at 24 h, 1.11 ± 0.85 at 48 h, and 0.94 ± 0.96 at 72 h. In group B, it was 3.82 ± 0.52 at 24 h, 3.64 ± 0.70 at 48 h, and 2.88 ± 1.26 at 72 h (P<.001, 95% CI). Conclusions In this study, topical administration of diltiazem resulted in a statistically significant reduction of postoperative pain in patients that underwent closed hemorrhoidectomy.
AB - Background Anal sphincter spasm contributes to the appearance of postoperative pain following hemorrhoidectomy. Aim To determine the efficacy of topical diltiazem in the control of post-hemorrhoidectomy pain. Material and methods A randomized, prospective, experimental, double-blind study was conducted on 2 groups of patients in the postoperative period of closed hemorrhoidectomy. Each group consisted of 17 patients. Group A received topical diltiazem in the anal region 3 times a day and group B received a placebo. Ketorolac was administered to both groups as rescue therapy. Results In group A, the mean score on the visual analog scale was 2.97 ± 1.18 cm at 24 h, 1.51 ± 1.18 cm at 48 h, and 0.84 ± 0.92 cm at 72 h. In group B, it was 6.82 ± 1.9 cm at 24 h, 5.3 ± 1.66 cm at 48 h, and 4.32 ± 2.13 cm at 72 h (P<.001, 95% CI). The mean number of analgesic doses in group A was 2.41 ± 0.87 at 24 h, 1.11 ± 0.85 at 48 h, and 0.94 ± 0.96 at 72 h. In group B, it was 3.82 ± 0.52 at 24 h, 3.64 ± 0.70 at 48 h, and 2.88 ± 1.26 at 72 h (P<.001, 95% CI). Conclusions In this study, topical administration of diltiazem resulted in a statistically significant reduction of postoperative pain in patients that underwent closed hemorrhoidectomy.
KW - Diltiazem;
KW - Hemorrhoidectomy
KW - Postoperative pain;
KW - Topical;
UR - http://www.scopus.com/inward/record.url?scp=84964771610&partnerID=8YFLogxK
U2 - 10.1016/j.rgmx.2016.02.001
DO - 10.1016/j.rgmx.2016.02.001
M3 - Artículo
SN - 0375-0906
VL - 81
SP - 74
EP - 79
JO - Revista de Gastroenterologia de Mexico
JF - Revista de Gastroenterologia de Mexico
IS - 2
ER -