TY - JOUR
T1 - Diindolylmethane derivatives as apoptosis inductors in L5178y cells
AU - Velasco-Bejarano, Benjamín
AU - Sánchez-Torres, Luvia Enid
AU - García-Estrada, José Guadalupe
AU - Miranda-Ruvalcaba, René
AU - Álvarez-Toledano, Cecilio
AU - Penieres-Carrillo, Guillermo
PY - 2008/7
Y1 - 2008/7
N2 - Cell growth and division are highly regulated processes, although a notable exception is provided by the cancer cell, which arises as a variant that has lost the usual proliferation control pathways. Consequently, there is growing interest in the search for antitumoral substances with high efficacy, low toxicity, and minimum side effects. In this sense, we synthesize eight diindolylmethane derivatives and the in vitro antitumor activity against murine L5178Y lymphoma cells was assessed. The preliminary results showed that the substituent and its position on the phenyl group were important for its potency against the lymphoma cells tested. Compound 3a was the most active compound with 93 % cell grown inhibition and 71.04% of apoptosis.
AB - Cell growth and division are highly regulated processes, although a notable exception is provided by the cancer cell, which arises as a variant that has lost the usual proliferation control pathways. Consequently, there is growing interest in the search for antitumoral substances with high efficacy, low toxicity, and minimum side effects. In this sense, we synthesize eight diindolylmethane derivatives and the in vitro antitumor activity against murine L5178Y lymphoma cells was assessed. The preliminary results showed that the substituent and its position on the phenyl group were important for its potency against the lymphoma cells tested. Compound 3a was the most active compound with 93 % cell grown inhibition and 71.04% of apoptosis.
KW - Apoptosis
KW - Cytotoxic effects
KW - DIM derivatives
KW - L5178Y cells
UR - http://www.scopus.com/inward/record.url?scp=77953814997&partnerID=8YFLogxK
M3 - Artículo
SN - 1870-249X
VL - 52
SP - 224
EP - 228
JO - Journal of the Mexican Chemical Society
JF - Journal of the Mexican Chemical Society
IS - 3
ER -