TY - JOUR
T1 - Differential gene expression in lymphocytes from malnourished children
AU - González, Cristina
AU - González, Haydeé
AU - Rodríguez, Leonor
AU - Cortés, Leticia
AU - Nájera, Oralia
AU - Hernández-Hernández, Fidel
AU - Flores, Luis
AU - Bonilla, Edmundo
PY - 2006/7
Y1 - 2006/7
N2 - Malnutrition, which is widespread in developing countries, may be particularly devastating during childhood, when tissue development is occurring and nutrient requirements are great. Since protein-energy malnutrition potentially involves many cellular alterations, we have evaluated gene expression changes in lymphocytes from malnourished children using differential hybridization cloning. A cDNA library was generated from well-nourished children and differential screenings were performed with cDNAs obtained from well-nourished and malnourished children who presented with bacterial gastrointestinal infections. Differential expression was detected for genes involved in cell development and differentiation, and for genes involved in lymphocyte and mitochondrial functions. The genes detected in the present study suggest mechanisms for the changes in cell growth and immune function that are associated with protein-energy malnutrition. Two down-regulated genes in malnourished children may represent mechanisms of protection against immunosuppression. This finding clearly merits further investigation.
AB - Malnutrition, which is widespread in developing countries, may be particularly devastating during childhood, when tissue development is occurring and nutrient requirements are great. Since protein-energy malnutrition potentially involves many cellular alterations, we have evaluated gene expression changes in lymphocytes from malnourished children using differential hybridization cloning. A cDNA library was generated from well-nourished children and differential screenings were performed with cDNAs obtained from well-nourished and malnourished children who presented with bacterial gastrointestinal infections. Differential expression was detected for genes involved in cell development and differentiation, and for genes involved in lymphocyte and mitochondrial functions. The genes detected in the present study suggest mechanisms for the changes in cell growth and immune function that are associated with protein-energy malnutrition. Two down-regulated genes in malnourished children may represent mechanisms of protection against immunosuppression. This finding clearly merits further investigation.
KW - Gene expression
KW - Malnutrition
KW - Protein energy malnutrition (PEM)
UR - http://www.scopus.com/inward/record.url?scp=33746661692&partnerID=8YFLogxK
U2 - 10.1016/j.cellbi.2006.02.011
DO - 10.1016/j.cellbi.2006.02.011
M3 - Artículo
C2 - 16731013
AN - SCOPUS:33746661692
SN - 1065-6995
VL - 30
SP - 610
EP - 614
JO - Cell Biology International
JF - Cell Biology International
IS - 7
ER -
