TY - JOUR
T1 - Differential expression of STAT5 and Bcl-xL, and high expression of Neu and STAT3 in non-small-cell lung carcinoma
AU - Sánchez-Ceja, S. G.
AU - Reyes-Maldonado, E.
AU - Vázquez-Manríquez, M. E.
AU - López-Luna, J. J.
AU - Belmont, A.
AU - Gutiérrez-Castellanos, S.
N1 - Funding Information:
Sanchez-Ceja SG is a recipient of a CONACYT grant (México). We wish to thank M.C. Renata Saucedo for help in statistical analysis of data. Reyes-Maldonado E is fellow COFAA and EDI, IPN. Gutiérrez-Castellanos S is fellow SNI.
PY - 2006/11
Y1 - 2006/11
N2 - Experimental evidence suggests that in lung cancer, development, progression and an increased proliferation rate can be linked to apoptosis-related factors. The objective of this study is to evaluate the status of Neu, signal transducer and activator of transcription (STAT)-3, STAT5 and Bcl-xL expression in non-small-cell lung cancer. We investigated the immunohistochemical expression of these proteins in 92 non-small-cell lung cancer specimens to establish their role in lung cancer pathogenesis. Neu was overexpressed in 65% of cases, and although STAT3 was overexpressed in 52.1% in cytoplasm, it was expressed in nucleus (activated) in 60.8%. Meanwhile, STAT5 was found overexpressed in 41.3% in cytoplasm and 32.6% in nucleus. Thus, Bcl-xL was overexpressed in cytoplasm in 81.5%. Interestingly, we found nuclear expression of Bcl-xL in 30.4% of cases. Finally, we found correlation among histological types of lung cancer and nuclear expression of both STAT5 (P = 0.005) and nuclear Bcl-xL (P = 0.003). Besides, nuclear expression of Bcl-xL was correlated with TNM stage IV (distant metastasis) (P = 0.02). These results suggest for the first time, a relevant role for STAT5 and Bcl-xL as apoptosis-regulatory proteins in the pathogenesis of lung cancer, and overexpression of both Neu and activated STAT3, could be related with the proliferation rate in lung carcinoma cells.
AB - Experimental evidence suggests that in lung cancer, development, progression and an increased proliferation rate can be linked to apoptosis-related factors. The objective of this study is to evaluate the status of Neu, signal transducer and activator of transcription (STAT)-3, STAT5 and Bcl-xL expression in non-small-cell lung cancer. We investigated the immunohistochemical expression of these proteins in 92 non-small-cell lung cancer specimens to establish their role in lung cancer pathogenesis. Neu was overexpressed in 65% of cases, and although STAT3 was overexpressed in 52.1% in cytoplasm, it was expressed in nucleus (activated) in 60.8%. Meanwhile, STAT5 was found overexpressed in 41.3% in cytoplasm and 32.6% in nucleus. Thus, Bcl-xL was overexpressed in cytoplasm in 81.5%. Interestingly, we found nuclear expression of Bcl-xL in 30.4% of cases. Finally, we found correlation among histological types of lung cancer and nuclear expression of both STAT5 (P = 0.005) and nuclear Bcl-xL (P = 0.003). Besides, nuclear expression of Bcl-xL was correlated with TNM stage IV (distant metastasis) (P = 0.02). These results suggest for the first time, a relevant role for STAT5 and Bcl-xL as apoptosis-regulatory proteins in the pathogenesis of lung cancer, and overexpression of both Neu and activated STAT3, could be related with the proliferation rate in lung carcinoma cells.
KW - Bcl-x
KW - Lung cancer
KW - NSCLC
KW - Neu
KW - STAT3
KW - STAT5
UR - http://www.scopus.com/inward/record.url?scp=33751362668&partnerID=8YFLogxK
U2 - 10.1016/j.lungcan.2006.07.012
DO - 10.1016/j.lungcan.2006.07.012
M3 - Artículo
C2 - 16959370
SN - 0169-5002
VL - 54
SP - 163
EP - 168
JO - Lung Cancer
JF - Lung Cancer
IS - 2
ER -