TY - JOUR
T1 - Design and synthesis of naphthol derivative using three components system and its relation with physicochemical parameters log P and π
AU - Figueroa-Valverde, L.
AU - Díaz-Cedillo, F.
AU - García-Cervera, E.
AU - Gómez, E. Pool
AU - Cordova-Vazquez, Johany
PY - 2013
Y1 - 2013
N2 - A naphthol derivative was synthesized using the three-component system (β-naphthol, benzaldehyde and N-(2-aminoethyl)-4-hydroxybenzamide) and characterized by spectral analyses. In order to characterize the structural and chemical requirements of naphthol derivative, some parameters such as log P and π were evaluated. The results showed an increase in the values of log P and π for the compound 4 in comparison with 1, 2 and 3. These data indicate a high degree of lipophilicity and steric impediment for compound 4 in comparison with 1, 2 and 3.
AB - A naphthol derivative was synthesized using the three-component system (β-naphthol, benzaldehyde and N-(2-aminoethyl)-4-hydroxybenzamide) and characterized by spectral analyses. In order to characterize the structural and chemical requirements of naphthol derivative, some parameters such as log P and π were evaluated. The results showed an increase in the values of log P and π for the compound 4 in comparison with 1, 2 and 3. These data indicate a high degree of lipophilicity and steric impediment for compound 4 in comparison with 1, 2 and 3.
KW - Derivatives
KW - Naphthol
KW - Synthesis
UR - http://www.scopus.com/inward/record.url?scp=84875183537&partnerID=8YFLogxK
U2 - 10.14233/ajchem.2013.13905
DO - 10.14233/ajchem.2013.13905
M3 - Artículo
SN - 0970-7077
VL - 25
SP - 3421
EP - 3423
JO - Asian Journal of Chemistry
JF - Asian Journal of Chemistry
IS - 6
ER -