TY - JOUR
T1 - Delta-sarcoglycan gene polymorphism frequency in Amerindian and Mestizo populations of Mexico
AU - Ordoñez-Razo, Rosa María
AU - Canizales-Quinteros, Samuel
AU - Rodríguez-Cruz, Maricela
AU - Peñaloza, Rosenda
AU - Minauro-Sanmiguel, Fernando
AU - Canto-Cetina, Thelma
AU - Canto, Patricia
AU - Coral-Vázquez, Ramón
AU - Salamanca-Gómez, Fabio
PY - 2010/4/1
Y1 - 2010/4/1
N2 - Mutations on the delta-sarcoglycan gene have been associated with the development of both hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy. Recently, the polymorphism c.-94C>G was associated with HCM in Japanese patients. The aim of our study was to evaluate the frequency of c.-94C>G polymorphism in Mexican-Amerindian and Mexican-Mestizo populations. We analyzed the frequency of this polymorphism in 165 Mexican-Amerindian individuals (23 Triquis, 25 Zapotecos, 24 Mayas, 41 Nahuas, and 52 Mixtecos) and 100 unrelated Mexican-Mestizos. Allele frequencies were similar in all Amerindian groups (0.33 Triquis, 0.54 Zapotecos, 0.54 Mayas, 0.46 Nahuas, and 0.49 Mixtecos). When compared with Mexican-Mestizos, only Triquis were different (p=0.00742). However, when comparing the total sample of the Amerindian population with the Mestizos, the difference was not significant (p=0.12225). Allele frequencies of Mexican populations were higher than in Asians and less than African and European populations (p<0.05). These data show that the distribution of the C allele is higher in Mexican populations studied and consequently it is necessary to define if this may be associated with genetic susceptibility for HCM in the Mexican patients.
AB - Mutations on the delta-sarcoglycan gene have been associated with the development of both hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy. Recently, the polymorphism c.-94C>G was associated with HCM in Japanese patients. The aim of our study was to evaluate the frequency of c.-94C>G polymorphism in Mexican-Amerindian and Mexican-Mestizo populations. We analyzed the frequency of this polymorphism in 165 Mexican-Amerindian individuals (23 Triquis, 25 Zapotecos, 24 Mayas, 41 Nahuas, and 52 Mixtecos) and 100 unrelated Mexican-Mestizos. Allele frequencies were similar in all Amerindian groups (0.33 Triquis, 0.54 Zapotecos, 0.54 Mayas, 0.46 Nahuas, and 0.49 Mixtecos). When compared with Mexican-Mestizos, only Triquis were different (p=0.00742). However, when comparing the total sample of the Amerindian population with the Mestizos, the difference was not significant (p=0.12225). Allele frequencies of Mexican populations were higher than in Asians and less than African and European populations (p<0.05). These data show that the distribution of the C allele is higher in Mexican populations studied and consequently it is necessary to define if this may be associated with genetic susceptibility for HCM in the Mexican patients.
UR - http://www.scopus.com/inward/record.url?scp=77950967746&partnerID=8YFLogxK
U2 - 10.1089/gtmb.2009.0147
DO - 10.1089/gtmb.2009.0147
M3 - Artículo
C2 - 20384457
SN - 1945-0265
VL - 14
SP - 237
EP - 240
JO - Genetic Testing and Molecular Biomarkers
JF - Genetic Testing and Molecular Biomarkers
IS - 2
ER -