TY - JOUR
T1 - Cytotoxic compounds from Laurencia pacifica
AU - Zaleta-Pinet, Diana A.
AU - Holland, Ian P.
AU - Muñoz-Ochoa, Mauricio
AU - Murillo-Alvarez, J. Ivan
AU - Sakoff, Jennette A.
AU - van Altena, Ian A.
AU - McCluskey, Adam
N1 - Publisher Copyright:
© 2014 Zaleta-Pinet et al.
PY - 2014
Y1 - 2014
N2 - Background: The current investigation sought to explore the nature of the secondary metabolites in the algae, Laurencia pacifica. Results: This report details the first isolation of the sesquiterpenes isoaplysin (1), isolaurenisol (2), debromoisolaurinterol (3), debromoaplysinol (4), laur-11-en-10-ol (5), 10α-hydroxyldebromoepiaplysin (6), and the previously unknown 10-bromo-3,7,11,11-tetramethylspiro[5.5]undeca-1,7-dien-3-ol (7) from the algae, Laurencia pacifica. Isoaplysin (1) and debromoaplysinol (4) showed promising levels of growth inhibition against a panel cancer-derived cell lines of colon (HT29), glioblastoma (U87, SJ-G2), breast (MCF-7), ovarian (A2780), lung (H460), skin (A431), prostate (Du145), neuroblastoma (BE2-C), pancreas (MIA), murine glioblastoma (SMA) origin with average GI50 values of 23 and 14 μM. Conclusions: Isoaplysin (1) and debromoaplysinol (4) were up to fourfold more potent in cancer-derived cell populations than in non-tumor-derived normal cells (MCF10A). These analogues are promising candidates for anticancer drug development.
AB - Background: The current investigation sought to explore the nature of the secondary metabolites in the algae, Laurencia pacifica. Results: This report details the first isolation of the sesquiterpenes isoaplysin (1), isolaurenisol (2), debromoisolaurinterol (3), debromoaplysinol (4), laur-11-en-10-ol (5), 10α-hydroxyldebromoepiaplysin (6), and the previously unknown 10-bromo-3,7,11,11-tetramethylspiro[5.5]undeca-1,7-dien-3-ol (7) from the algae, Laurencia pacifica. Isoaplysin (1) and debromoaplysinol (4) showed promising levels of growth inhibition against a panel cancer-derived cell lines of colon (HT29), glioblastoma (U87, SJ-G2), breast (MCF-7), ovarian (A2780), lung (H460), skin (A431), prostate (Du145), neuroblastoma (BE2-C), pancreas (MIA), murine glioblastoma (SMA) origin with average GI50 values of 23 and 14 μM. Conclusions: Isoaplysin (1) and debromoaplysinol (4) were up to fourfold more potent in cancer-derived cell populations than in non-tumor-derived normal cells (MCF10A). These analogues are promising candidates for anticancer drug development.
KW - Algae
KW - Anti-cancer
KW - Cytotoxicity
KW - Laurencia pacifica
KW - Sesquiterpenes
UR - http://www.scopus.com/inward/record.url?scp=85042949979&partnerID=8YFLogxK
U2 - 10.1186/s13588-014-0008-8
DO - 10.1186/s13588-014-0008-8
M3 - Artículo
AN - SCOPUS:85042949979
SN - 2191-2858
VL - 4
JO - Organic and Medicinal Chemistry Letters
JF - Organic and Medicinal Chemistry Letters
IS - 1
M1 - 8
ER -
