Cooked Common Beans (Phaseolus vulgaris) Protect Against β-cell Damage in Streptozotocin-Induced Diabetic Rats

Diego Hernández-Saavedra, Magdalena Mendoza-Sánchez, Hebert L. Hernández-Montiel, Horacio S. Guzmán-Maldonado, Guadalupe F. Loarca-Piña, Luis M. Salgado, Rosalía Reynoso-Camacho

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Diabetes is a disease characterized by a hyperglycemic stage that leads to a chronic inflammatory state. We evaluated the in vivo effect of a diet supplemented with 25 % cooked black bean cultivar Negro 8025 (N8025) flour in streptozotocin-induced diabetic rats. The effect was assessed before (preventive-treatment) and after (treatment) the onset of diabetes. There is a significant decrease of total phenolic, tannins and anthocyanins content after cooking, and the concentration of most of the single phenols analyzed are only slightly decreased. The treatment group showed a significant reduction of glucose (22.8 %), triglycerides (21.9 %), total cholesterol (29.9 %) and LDL (56.1 %) that correlates with a protection of pancreatic ß-cells. The diet with N8025 flour before the induction of diabetes did not exert a protective effect (glucose levels are similar to the diabetic control) but they have low levels of total cholesterol (47.5 %) and LDL (56.1 %). The preventive-treatment group did not inhibit the increase of TNF-α and IL-1β, whereas the treatment group did, compared to the diabetic control. Therefore, N8025 bean supplementation can be recommended to control diabetes. © 2013 Springer Science+Business Media New York.
Original languageAmerican English
Pages (from-to)207-212
Number of pages6
JournalPlant Foods for Human Nutrition
DOIs
StatePublished - 1 Jun 2013

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Phaseolus
streptozotocin
Streptozocin
Medical problems
Phaseolus vulgaris
diabetes
Rats
beans
African Americans
Cells
rats
Nutrition
LDL Cholesterol
flour
Flour
cholesterol
cells
black beans
Glucose
glucose

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Hernández-Saavedra, D., Mendoza-Sánchez, M., Hernández-Montiel, H. L., Guzmán-Maldonado, H. S., Loarca-Piña, G. F., Salgado, L. M., & Reynoso-Camacho, R. (2013). Cooked Common Beans (Phaseolus vulgaris) Protect Against β-cell Damage in Streptozotocin-Induced Diabetic Rats. Plant Foods for Human Nutrition, 207-212. https://doi.org/10.1007/s11130-013-0353-1
Hernández-Saavedra, Diego ; Mendoza-Sánchez, Magdalena ; Hernández-Montiel, Hebert L. ; Guzmán-Maldonado, Horacio S. ; Loarca-Piña, Guadalupe F. ; Salgado, Luis M. ; Reynoso-Camacho, Rosalía. / Cooked Common Beans (Phaseolus vulgaris) Protect Against β-cell Damage in Streptozotocin-Induced Diabetic Rats. In: Plant Foods for Human Nutrition. 2013 ; pp. 207-212.
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Hernández-Saavedra, D, Mendoza-Sánchez, M, Hernández-Montiel, HL, Guzmán-Maldonado, HS, Loarca-Piña, GF, Salgado, LM & Reynoso-Camacho, R 2013, 'Cooked Common Beans (Phaseolus vulgaris) Protect Against β-cell Damage in Streptozotocin-Induced Diabetic Rats', Plant Foods for Human Nutrition, pp. 207-212. https://doi.org/10.1007/s11130-013-0353-1

Cooked Common Beans (Phaseolus vulgaris) Protect Against β-cell Damage in Streptozotocin-Induced Diabetic Rats. / Hernández-Saavedra, Diego; Mendoza-Sánchez, Magdalena; Hernández-Montiel, Hebert L.; Guzmán-Maldonado, Horacio S.; Loarca-Piña, Guadalupe F.; Salgado, Luis M.; Reynoso-Camacho, Rosalía.

In: Plant Foods for Human Nutrition, 01.06.2013, p. 207-212.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cooked Common Beans (Phaseolus vulgaris) Protect Against β-cell Damage in Streptozotocin-Induced Diabetic Rats

AU - Hernández-Saavedra, Diego

AU - Mendoza-Sánchez, Magdalena

AU - Hernández-Montiel, Hebert L.

AU - Guzmán-Maldonado, Horacio S.

AU - Loarca-Piña, Guadalupe F.

AU - Salgado, Luis M.

AU - Reynoso-Camacho, Rosalía

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Diabetes is a disease characterized by a hyperglycemic stage that leads to a chronic inflammatory state. We evaluated the in vivo effect of a diet supplemented with 25 % cooked black bean cultivar Negro 8025 (N8025) flour in streptozotocin-induced diabetic rats. The effect was assessed before (preventive-treatment) and after (treatment) the onset of diabetes. There is a significant decrease of total phenolic, tannins and anthocyanins content after cooking, and the concentration of most of the single phenols analyzed are only slightly decreased. The treatment group showed a significant reduction of glucose (22.8 %), triglycerides (21.9 %), total cholesterol (29.9 %) and LDL (56.1 %) that correlates with a protection of pancreatic ß-cells. The diet with N8025 flour before the induction of diabetes did not exert a protective effect (glucose levels are similar to the diabetic control) but they have low levels of total cholesterol (47.5 %) and LDL (56.1 %). The preventive-treatment group did not inhibit the increase of TNF-α and IL-1β, whereas the treatment group did, compared to the diabetic control. Therefore, N8025 bean supplementation can be recommended to control diabetes. © 2013 Springer Science+Business Media New York.

AB - Diabetes is a disease characterized by a hyperglycemic stage that leads to a chronic inflammatory state. We evaluated the in vivo effect of a diet supplemented with 25 % cooked black bean cultivar Negro 8025 (N8025) flour in streptozotocin-induced diabetic rats. The effect was assessed before (preventive-treatment) and after (treatment) the onset of diabetes. There is a significant decrease of total phenolic, tannins and anthocyanins content after cooking, and the concentration of most of the single phenols analyzed are only slightly decreased. The treatment group showed a significant reduction of glucose (22.8 %), triglycerides (21.9 %), total cholesterol (29.9 %) and LDL (56.1 %) that correlates with a protection of pancreatic ß-cells. The diet with N8025 flour before the induction of diabetes did not exert a protective effect (glucose levels are similar to the diabetic control) but they have low levels of total cholesterol (47.5 %) and LDL (56.1 %). The preventive-treatment group did not inhibit the increase of TNF-α and IL-1β, whereas the treatment group did, compared to the diabetic control. Therefore, N8025 bean supplementation can be recommended to control diabetes. © 2013 Springer Science+Business Media New York.

U2 - 10.1007/s11130-013-0353-1

DO - 10.1007/s11130-013-0353-1

M3 - Article

C2 - 23595343

SP - 207

EP - 212

JO - Plant Foods for Human Nutrition

JF - Plant Foods for Human Nutrition

SN - 0921-9668

ER -

Hernández-Saavedra D, Mendoza-Sánchez M, Hernández-Montiel HL, Guzmán-Maldonado HS, Loarca-Piña GF, Salgado LM et al. Cooked Common Beans (Phaseolus vulgaris) Protect Against β-cell Damage in Streptozotocin-Induced Diabetic Rats. Plant Foods for Human Nutrition. 2013 Jun 1;207-212. https://doi.org/10.1007/s11130-013-0353-1