Mexico is a country that makes heavy use of the shark populations that inhabit the southern portion of the Northeast Pacific Ocean (NEP). Shark meat has become an essential food source in this country, while shark fins are used to supply traditional Asian markets. In addition to consumptive utilization, charismatic shark species support an ecotourism industry that has gained significance in several tourist resorts across the country. In this concluding chapter, we recap the contents of chapters included in volumes 83 and 85 in the Advances in Marine Biology series. The chapters in these volumes address biodiversity, conservation genetics, trophic ecology, migratory movements, fisheries, and shark ecotourism, allowing us to understand the state of knowledge relevant to human: shark interactions in the Mexican Pacific. We discuss the challenges for the sustainable use and conservation of sharks in the southern NEP and highlight the need for a more holistic management approach that includes economic and social factors. To meet these challenges, we recommend updating the Mexican National Plan of Action for Sharks published in, 2004, such that it may continue serving as a roadmap for the conservation and management of sharks in the southern NEP during the years to come.