Comparison of virulence of Mycobacteriurn avium complex (MAC) strains isolated from AIDS and non-AIDS patients

Venkata M. Reddy; Kishori Parikh; Julieta Luna-Herrera; Joseph O. Falkinham; Sheldon Brown; Pattisapu R.J. Gangadharam

doi:10.1006/mpat.1994.1013

Comparison of virulence of Mycobacteriurn avium complex (MAC) strains isolated from AIDS and non-AIDS patients

Venkata M. Reddy, Kishori Parikh, Julieta Luna-Herrera, Joseph O. Falkinham, Sheldon Brown, Pattisapu R.J. Gangadharam

Research output: Contribution to journal › Article › peer-review

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Abstract

Mycobacterium avium complex (MAC) strains from AIDS and non-AIDS patients and from the environment were studied for their colony morphology and virulence in beige mice. The majority of the MAC isolates from AIDS patients, in contrast to those from non-AIDS patients and the environment, showed increased virulence. Similarly, the majority of the MAC isolates from AIDS patients formed smooth transparent (ST) colonies, whereas most of the non-AIDS isolates formed smooth opaque (SO) or intermediate (IM) type of colonies. MAC isolates from the same AIDS patient obtained at different times were found to be heterogenic with respect to serotype, RFLP and glycolipid patterns, suggesting that these patients might be infected with more than one strain of MAC.

Original language	English
Pages (from-to)	121-130
Number of pages	10
Journal	Microbial Pathogenesis
Volume	16
Issue number	2
DOIs	https://doi.org/10.1006/mpat.1994.1013
State	Published - Feb 1994
Externally published	Yes

Keywords

Mycobacterium avium complex (MAC); virulence; multiple isolates; AIDS and non-AIDS patients; colony morphology

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10.1006/mpat.1994.1013

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abstract = "Mycobacterium avium complex (MAC) strains from AIDS and non-AIDS patients and from the environment were studied for their colony morphology and virulence in beige mice. The majority of the MAC isolates from AIDS patients, in contrast to those from non-AIDS patients and the environment, showed increased virulence. Similarly, the majority of the MAC isolates from AIDS patients formed smooth transparent (ST) colonies, whereas most of the non-AIDS isolates formed smooth opaque (SO) or intermediate (IM) type of colonies. MAC isolates from the same AIDS patient obtained at different times were found to be heterogenic with respect to serotype, RFLP and glycolipid patterns, suggesting that these patients might be infected with more than one strain of MAC.",

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AU - Falkinham, Joseph O.

AU - Brown, Sheldon

AU - Gangadharam, Pattisapu R.J.

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Comparison of virulence of Mycobacteriurn avium complex (MAC) strains isolated from AIDS and non-AIDS patients

Abstract

Keywords

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