TY - JOUR
T1 - Comparison of organochlorine pesticide levels between human blood serum and adipose tissue
AU - Martínez-Valenzuela, María Del Carmen
AU - Waliszewski, Stefan M.
AU - Gómez-Arroyo, Sandra
AU - Villalobos-Pietrini, Rafael
AU - Calderón-Vázquez, Carlos
AU - Ortega-Martínez, Daniel
AU - Meza, Enrique
AU - Caba, Mario
N1 - Publisher Copyright:
© 2016 Centro de Ciencias de la Atmosfera, UNAM. All rights reserved.
PY - 2017
Y1 - 2017
N2 - The organochlorine pesticides, being lipophilic compounds, show extremely high thermodynamic stability and resistance to degradation processes in the environment and in living organisms. They accumulate in lipid rich tissues and distribute between transport compartment (blood) and store compartment (adipose tissue). The purpose of this study is to make a comparison between organochlorine pesticide levels in blood serum and adipose tissue and calculate the differences in their concentrations based on routine biomonitoring study. One hundred and twenty six pair samples of adipose tissue and blood serum during autopsies as a case study were taken and analyzed in Los Mochis Sinaloa, México. Among organochlorine pesticides, higher concentrations correspond to b-HCH, pp’DDE and op’DDT in blood serum lipids; and pp’DDT shows higher concentrations in adipose tissue. Using statistical comparisons, we found a significant linear association of lipid serum organochlorine pesticide concentrations with that in adipose tissue. This concludes that serum lipid organochlorine pesticide concentrations represent an important indicator for both human biological matrices.
AB - The organochlorine pesticides, being lipophilic compounds, show extremely high thermodynamic stability and resistance to degradation processes in the environment and in living organisms. They accumulate in lipid rich tissues and distribute between transport compartment (blood) and store compartment (adipose tissue). The purpose of this study is to make a comparison between organochlorine pesticide levels in blood serum and adipose tissue and calculate the differences in their concentrations based on routine biomonitoring study. One hundred and twenty six pair samples of adipose tissue and blood serum during autopsies as a case study were taken and analyzed in Los Mochis Sinaloa, México. Among organochlorine pesticides, higher concentrations correspond to b-HCH, pp’DDE and op’DDT in blood serum lipids; and pp’DDT shows higher concentrations in adipose tissue. Using statistical comparisons, we found a significant linear association of lipid serum organochlorine pesticide concentrations with that in adipose tissue. This concludes that serum lipid organochlorine pesticide concentrations represent an important indicator for both human biological matrices.
KW - Biological matrices
KW - Fat tissue
KW - Plasma
KW - Toxicokinetic
UR - http://www.scopus.com/inward/record.url?scp=85026731897&partnerID=8YFLogxK
U2 - 10.20937/RICA.2017.33.03.03
DO - 10.20937/RICA.2017.33.03.03
M3 - Artículo
SN - 0188-4999
VL - 33
SP - 393
EP - 401
JO - Revista Internacional de Contaminacion Ambiental
JF - Revista Internacional de Contaminacion Ambiental
IS - 3
ER -