TY - JOUR
T1 - Comparative study of enalapril vs. losartan on residual renal function preservation in automated peritoneal dialysis. A randomized controlled study
AU - Reyes-Marín, Fernando Arturo
AU - Calzada, Claudia
AU - Ballesteros, Araceli
AU - Amato, Dante
PY - 2012/7
Y1 - 2012/7
N2 - Background. Residual renal function (RRF) is an important determinant of mortality and morbidity in patients receiving peritoneal dialysis (PD). Recent studies have shown a positive effect of angiotensin converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARBs) on RRF in PD patients. Objective. To compare enalapril and losartan for RRF preservation in automated peritoneal dialysis (APD) patients. Material and methods. An open label randomized controlled trial (RCT) with a 12 month follow-up period was conducted to compare the effect of enalapril vs. losartan on RRF preservation in 60 APD patients. Measurements were done at the start of the study (baseline), 3, 6, 9, and 12 months. A historical control group (HCG) without treatment was included to assess the natural history of RRF loss. Results. RRF in the enalapril group dropped from 3.65 ± 1.6 (baseline) to 2.36 ± 0.38 mL/min/1.73 m2 (12 months). In the losartan group RRF was reduced from 4.1± 2.01 (baseline) to 2.54 ± 0.47 mL/min/1.73m2 (12 months). There were not significant differences between the two groups regarding RRF at 12 months. In the HCG, RRF declined from 3.68 ± 0.48 to 1.4± 0.29 mL/min/1.73m2 (12 months). RRF in the HCG was significantly lower than RRF in the two treated groups at 12 months (P < 0.05). Conclusions. There was not significant difference on RRF preservation between enalapril and losartan groups. Comparing these results to those of the HCG suggests that the treatment with any of the drugs is useful in preserving RRF.
AB - Background. Residual renal function (RRF) is an important determinant of mortality and morbidity in patients receiving peritoneal dialysis (PD). Recent studies have shown a positive effect of angiotensin converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARBs) on RRF in PD patients. Objective. To compare enalapril and losartan for RRF preservation in automated peritoneal dialysis (APD) patients. Material and methods. An open label randomized controlled trial (RCT) with a 12 month follow-up period was conducted to compare the effect of enalapril vs. losartan on RRF preservation in 60 APD patients. Measurements were done at the start of the study (baseline), 3, 6, 9, and 12 months. A historical control group (HCG) without treatment was included to assess the natural history of RRF loss. Results. RRF in the enalapril group dropped from 3.65 ± 1.6 (baseline) to 2.36 ± 0.38 mL/min/1.73 m2 (12 months). In the losartan group RRF was reduced from 4.1± 2.01 (baseline) to 2.54 ± 0.47 mL/min/1.73m2 (12 months). There were not significant differences between the two groups regarding RRF at 12 months. In the HCG, RRF declined from 3.68 ± 0.48 to 1.4± 0.29 mL/min/1.73m2 (12 months). RRF in the HCG was significantly lower than RRF in the two treated groups at 12 months (P < 0.05). Conclusions. There was not significant difference on RRF preservation between enalapril and losartan groups. Comparing these results to those of the HCG suggests that the treatment with any of the drugs is useful in preserving RRF.
KW - ACE inhibitors
KW - Angiotensin II blockers
KW - Automated peritoneal dialysis
KW - Randomized controlled trial
KW - Residual renal function
UR - http://www.scopus.com/inward/record.url?scp=84869825331&partnerID=8YFLogxK
M3 - Artículo
SN - 0034-8376
VL - 64
SP - 315
EP - 321
JO - Revista de Investigacion Clinica
JF - Revista de Investigacion Clinica
IS - 4
ER -