Comparative bioavailability of two oral formulations of ketorolac tromethamine: Dolac® and Exodol®

Francisco J. Flores‐Murrieta, Vinicio Granados‐Soto, Gilberto Castañeda‐Hernández, Jorge E. Herrera, Enrique Hong

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The bioavailability of ketorolac after administration of two oral formulations containing 10 mg of ketorolac tromethamine, Exodol® and Dolac®, to 12 healthy Mexican volunteers was compared. Subjects received both formulations according to a randomized crossover design and blood samples were drawn at selected times during 24 h. Ketorolac plasma concentrations were determined by HPLC and individual plasma‐concentration‐against‐time curves were constructed. Maximal plasma concentration and AUC0‐24. values were compared by analysis of variance followed by Westlake's confidence interval test. 90% confidence limits ranged from 80 to 125% for Cmax and from 85 to 118% for AUC0‐24. It is concluded that the two assayed formulations are bioequivalent. Copyright © 1994 John Wiley & Sons, Ltd.
Original languageAmerican English
Pages (from-to)129-136
Number of pages115
JournalBiopharmaceutics & Drug Disposition
StatePublished - 1 Jan 1994
Externally publishedYes


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