TY - JOUR
T1 - Compactibility of agglomerated mixtures of calcium carbonate and microcrystalline cellulose
AU - De Lourdes Garzón Serra, María
AU - Villafuerte Robles, Leopoldo
PY - 2003/6/4
Y1 - 2003/6/4
N2 - The tablet tensile strength (T) of agglomerated mixtures of microcrystalline cellulose - Avicel PH 102 (MC), calcium carbonate (CC) and polyvinylpyrrolidone (Povidone, PVP), lubricated with magnesium stearate (MS), and formed under a compaction pressure (Pc) ranging up to 618MPa has been determined. The compactibility was defined through: ln(-ln(1-T/Tmax))=Slope×lnPc+Intercept. MC/CC mixtures added of an agglutinant, before and after lubrication, show an important positive effect on their tablet tensile strength compared to a lineal relationship. This positive effect becomes smaller with decreasing compaction pressures. By different mixing methods, the higher the mixing efficiency the higher the compactibility, following the order: spray-dried>wet massing>tumble mixing. The compactibility of MC/CC/PVP spray-dried mixtures with calcium carbonate content from 20 to 60% was equal to or greater than that of pure microcrystalline cellulose. After lubrication with 2% MS the compactibility decreased, only the mixture with the maximal tablet tensile strength attained the tensile strength of pure microcrystalline cellulose. The presence of the binder, the lubricant and higher compaction pressures allow the accommodation of higher calcium carbonate proportions in the mixtures, at the maximal tablet tensile strength of the series. The lubricant decreases in a greater extent the compactibility of mixtures with a continuous phase of MC/PVP than that of CC/PVP. This is attributed to the plastic behavior of the MC/PVP continuous phase compared to a calcium carbonate continuous phase able to disrupt the Povidone and the possible lubricant coatings allowing a stronger interparticle interaction.
AB - The tablet tensile strength (T) of agglomerated mixtures of microcrystalline cellulose - Avicel PH 102 (MC), calcium carbonate (CC) and polyvinylpyrrolidone (Povidone, PVP), lubricated with magnesium stearate (MS), and formed under a compaction pressure (Pc) ranging up to 618MPa has been determined. The compactibility was defined through: ln(-ln(1-T/Tmax))=Slope×lnPc+Intercept. MC/CC mixtures added of an agglutinant, before and after lubrication, show an important positive effect on their tablet tensile strength compared to a lineal relationship. This positive effect becomes smaller with decreasing compaction pressures. By different mixing methods, the higher the mixing efficiency the higher the compactibility, following the order: spray-dried>wet massing>tumble mixing. The compactibility of MC/CC/PVP spray-dried mixtures with calcium carbonate content from 20 to 60% was equal to or greater than that of pure microcrystalline cellulose. After lubrication with 2% MS the compactibility decreased, only the mixture with the maximal tablet tensile strength attained the tensile strength of pure microcrystalline cellulose. The presence of the binder, the lubricant and higher compaction pressures allow the accommodation of higher calcium carbonate proportions in the mixtures, at the maximal tablet tensile strength of the series. The lubricant decreases in a greater extent the compactibility of mixtures with a continuous phase of MC/PVP than that of CC/PVP. This is attributed to the plastic behavior of the MC/PVP continuous phase compared to a calcium carbonate continuous phase able to disrupt the Povidone and the possible lubricant coatings allowing a stronger interparticle interaction.
KW - Agglomerated mixtures
KW - Agglutinants
KW - Calcium carbonate
KW - Compactibility
KW - Lubricants
KW - Microcrystalline cellulose
KW - Tablet tensile strength
UR - http://www.scopus.com/inward/record.url?scp=0038175048&partnerID=8YFLogxK
U2 - 10.1016/S0378-5173(03)00185-6
DO - 10.1016/S0378-5173(03)00185-6
M3 - Artículo
SN - 0378-5173
VL - 258
SP - 153
EP - 163
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1-2
ER -