TY - JOUR
T1 - Co-infection between genotypes of the human papillomavirus and Chlamydia trachomatis in Mexican women
AU - Escarcega-Tame, Marco A.
AU - López-Hurtado, Marcela
AU - Escobedo-Guerra, Marcos R.
AU - Reyes-Maldonado, Elba
AU - Castro-Escarpulli, Graciela
AU - Guerra-Infante, Fernando M.
N1 - Publisher Copyright:
© The Author(s) 2020.
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Not all human papillomavirus (HPV) infections develop into cervical cancer (CC), so it is proposed that other factors may influence this, such as co-infection with Chlamydia trachomatis (CT). To identify the prevalence of co-infection, we included 189 women with suspicion of HPV. Viral typing was performed by carrying out the Roche HP Linear Array test, while CT detection was performed with the COBAS® TaqMan® 48 kit from Roche. Of the 189 women only 184 had an infection with HPV, CT or both: 56.6% were positive for one or several HPV genotypes, and 67.7% for CT. Clinical data showed an association between HPV and CIN I (n = 22; RR = 2.43; 95% CI 1.72–3.43, p < 0.05). CT infection was only associated with cervicitis (n = 40; RR = 1.73; 95% CI 1.34–2.23, p < 0.05). The CT-HPV co-infection rate was 28%. Co-infection revealed an association with CIN I (n = 31, RR= 3.33; 95% CI 2.08–5.34 p < 0.05), CIN III (n = 7; RR = 2.57; 95% CI 1.53–4.31, p < 0.05); and a significant risk of 2.3 (95% CI 1.08–4.90) times higher to develop CC; nevertheless, this risk was not statistically significant. CT/HPV co-infection was associated with the development of a high-grade lesion (CIN III) as well as an important risk for developing CC.
AB - Not all human papillomavirus (HPV) infections develop into cervical cancer (CC), so it is proposed that other factors may influence this, such as co-infection with Chlamydia trachomatis (CT). To identify the prevalence of co-infection, we included 189 women with suspicion of HPV. Viral typing was performed by carrying out the Roche HP Linear Array test, while CT detection was performed with the COBAS® TaqMan® 48 kit from Roche. Of the 189 women only 184 had an infection with HPV, CT or both: 56.6% were positive for one or several HPV genotypes, and 67.7% for CT. Clinical data showed an association between HPV and CIN I (n = 22; RR = 2.43; 95% CI 1.72–3.43, p < 0.05). CT infection was only associated with cervicitis (n = 40; RR = 1.73; 95% CI 1.34–2.23, p < 0.05). The CT-HPV co-infection rate was 28%. Co-infection revealed an association with CIN I (n = 31, RR= 3.33; 95% CI 2.08–5.34 p < 0.05), CIN III (n = 7; RR = 2.57; 95% CI 1.53–4.31, p < 0.05); and a significant risk of 2.3 (95% CI 1.08–4.90) times higher to develop CC; nevertheless, this risk was not statistically significant. CT/HPV co-infection was associated with the development of a high-grade lesion (CIN III) as well as an important risk for developing CC.
KW - Chlamydia trachomatis
KW - HPV51
KW - cervical intraepithelial neoplasia
KW - human papillomavirus
KW - sexually transmitted diseases
UR - http://www.scopus.com/inward/record.url?scp=85091739570&partnerID=8YFLogxK
U2 - 10.1177/0956462420947587
DO - 10.1177/0956462420947587
M3 - Artículo
C2 - 32998641
AN - SCOPUS:85091739570
SN - 0956-4624
VL - 31
SP - 1255
EP - 1262
JO - International Journal of STD and AIDS
JF - International Journal of STD and AIDS
IS - 13
ER -
