TY - JOUR
T1 - Clinical relevance of NKT cells and soluble MIC-A in Hodgkin lymphoma
AU - Vela-Ojeda, Jorge
AU - Perez-Retiguin, Flor Del Carmen
AU - Olivas-Bejarano, Ana Cristina
AU - Garcia-Ruiz Esparza, Miriam America
AU - Garcia-Chavez, Jaime
AU - Majluf-Cruz, Abraham
AU - Reyes-Maldonado, Elba
AU - Montiel-Cervantes, Laura Arcelia
N1 - Publisher Copyright:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - Previous studies demonstrated that the majority of Hodgkin lymphoma (HL) patients achieve response after treatment, while 5% become refractory. Studies analyzing the role of lymphocyte subsets in peripheral blood are limited. This investigation sought to evaluate peripheral blood lymphocyte subsets and soluble MHC class I chain-related proteins A and B (sMIC-A/B) and their correlation with survival in patients with newly diagnosed HL. The study recruited 36 patients and 72 healthy donors. HL patients showed a decrease in CD4, B, monocytes, NK, and NKT cells; and an increase in γ-δ T cells and soluble MIC-A serum levels. Higher values of s-MIC-A >100 ng/mL and NKT cells >40 µL correlated with poor overall survival (OS). In conclusion, in HL peripheral blood CD4 T and B cells, monocytes, NK, and NKT cells were decreased, while s-MIC-A and γ-δ T cells increased. Higher values of s-MIC-A and NKT cells correlated with poor survival.
AB - Previous studies demonstrated that the majority of Hodgkin lymphoma (HL) patients achieve response after treatment, while 5% become refractory. Studies analyzing the role of lymphocyte subsets in peripheral blood are limited. This investigation sought to evaluate peripheral blood lymphocyte subsets and soluble MHC class I chain-related proteins A and B (sMIC-A/B) and their correlation with survival in patients with newly diagnosed HL. The study recruited 36 patients and 72 healthy donors. HL patients showed a decrease in CD4, B, monocytes, NK, and NKT cells; and an increase in γ-δ T cells and soluble MIC-A serum levels. Higher values of s-MIC-A >100 ng/mL and NKT cells >40 µL correlated with poor overall survival (OS). In conclusion, in HL peripheral blood CD4 T and B cells, monocytes, NK, and NKT cells were decreased, while s-MIC-A and γ-δ T cells increased. Higher values of s-MIC-A and NKT cells correlated with poor survival.
KW - Hodgkin lymphoma
KW - NKT cells
KW - lymphocyte subsets
KW - sMIC-A
UR - http://www.scopus.com/inward/record.url?scp=85097316047&partnerID=8YFLogxK
U2 - 10.1080/10428194.2020.1852473
DO - 10.1080/10428194.2020.1852473
M3 - Artículo
C2 - 33284055
AN - SCOPUS:85097316047
SN - 1042-8194
VL - 62
SP - 801
EP - 809
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 4
ER -
