Cis and trans platinum(ii) N-heterocyclic carbene isomers: synthesis, characterization and biological activity

Carolina Rivera; Héctor A. Bacilio-Beltrán; Ana M. Puebla-Pérez; Irma I. Rangel-Salas; José G. Alvarado-Rodríguez; Roberto Flores-Moreno; Gilberto Velázquez-Juárez; A. Aarón Peregrina-Lucano; Elvia Becerra-Martínez; Jaime Valdez-Ruvalcaba; José E. Rubio; Sara A. Cortés-Llamas

doi:10.1039/d2nj02508f

Cis and trans platinum(ii) N-heterocyclic carbene isomers: synthesis, characterization and biological activity

Carolina Rivera, Héctor A. Bacilio-Beltrán, Ana M. Puebla-Pérez, Irma I. Rangel-Salas, José G. Alvarado-Rodríguez, Roberto Flores-Moreno, Gilberto Velázquez-Juárez, A. Aarón Peregrina-Lucano, Elvia Becerra-Martínez, Jaime Valdez-Ruvalcaba, José E. Rubio, Sara A. Cortés-Llamas

Centro de Nanociencias y Micro y Nanotecnologías (CNMN)

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The synthesis of cis and trans geometrical isomers of platinum(ii) complexes with a symmetric N-heterocyclic carbene ligand (^MeNHC) is reported. These complexes were obtained from 1,3-dimethylimidazolium-2-carboxylate, a masked NHC precursor. Their cytotoxicity, oxidative nature, and antibacterial behavior were investigated. The highest cytotoxic effect (IC₅₀ = 1.21 μM) was observed with the cis-[Pt(^MeNHC)₂Cl₂] complex in the cervix cancerous cell line HeLa.

Original language	English
Pages (from-to)	14221-14226
Number of pages	6
Journal	New Journal of Chemistry
Volume	46
Issue number	29
DOIs	https://doi.org/10.1039/d2nj02508f
State	Published - 27 Jun 2022

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Rivera, C., Bacilio-Beltrán, H. A., Puebla-Pérez, A. M., Rangel-Salas, I. I., Alvarado-Rodríguez, J. G., Flores-Moreno, R., Velázquez-Juárez, G., Peregrina-Lucano, A. A., Becerra-Martínez, E., Valdez-Ruvalcaba, J., Rubio, J. E., & Cortés-Llamas, S. A. (2022). Cis and trans platinum(ii) N-heterocyclic carbene isomers: synthesis, characterization and biological activity. New Journal of Chemistry, 46(29), 14221-14226. https://doi.org/10.1039/d2nj02508f

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title = "Cis and trans platinum(ii) N-heterocyclic carbene isomers: synthesis, characterization and biological activity",

abstract = "The synthesis of cis and trans geometrical isomers of platinum(ii) complexes with a symmetric N-heterocyclic carbene ligand (MeNHC) is reported. These complexes were obtained from 1,3-dimethylimidazolium-2-carboxylate, a masked NHC precursor. Their cytotoxicity, oxidative nature, and antibacterial behavior were investigated. The highest cytotoxic effect (IC50 = 1.21 μM) was observed with the cis-[Pt(MeNHC)2Cl2] complex in the cervix cancerous cell line HeLa.",

author = "Carolina Rivera and Bacilio-Beltr{\'a}n, {H{\'e}ctor A.} and Puebla-P{\'e}rez, {Ana M.} and Rangel-Salas, {Irma I.} and Alvarado-Rodr{\'i}guez, {Jos{\'e} G.} and Roberto Flores-Moreno and Gilberto Vel{\'a}zquez-Ju{\'a}rez and Peregrina-Lucano, {A. Aar{\'o}n} and Elvia Becerra-Mart{\'i}nez and Jaime Valdez-Ruvalcaba and Rubio, {Jos{\'e} E.} and Cort{\'e}s-Llamas, {Sara A.}",

note = "Publisher Copyright: {\textcopyright} 2022 The Royal Society of Chemistry.",

year = "2022",

month = jun,

day = "27",

doi = "10.1039/d2nj02508f",

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Rivera, C, Bacilio-Beltrán, HA, Puebla-Pérez, AM, Rangel-Salas, II, Alvarado-Rodríguez, JG, Flores-Moreno, R, Velázquez-Juárez, G, Peregrina-Lucano, AA, Becerra-Martínez, E, Valdez-Ruvalcaba, J, Rubio, JE & Cortés-Llamas, SA 2022, 'Cis and trans platinum(ii) N-heterocyclic carbene isomers: synthesis, characterization and biological activity', New Journal of Chemistry, vol. 46, no. 29, pp. 14221-14226. https://doi.org/10.1039/d2nj02508f

TY - JOUR

T1 - Cis and trans platinum(ii) N-heterocyclic carbene isomers

T2 - synthesis, characterization and biological activity

AU - Rivera, Carolina

AU - Bacilio-Beltrán, Héctor A.

AU - Puebla-Pérez, Ana M.

AU - Rangel-Salas, Irma I.

AU - Alvarado-Rodríguez, José G.

AU - Flores-Moreno, Roberto

AU - Velázquez-Juárez, Gilberto

AU - Peregrina-Lucano, A. Aarón

AU - Becerra-Martínez, Elvia

AU - Valdez-Ruvalcaba, Jaime

AU - Rubio, José E.

AU - Cortés-Llamas, Sara A.

PY - 2022/6/27

Y1 - 2022/6/27

N2 - The synthesis of cis and trans geometrical isomers of platinum(ii) complexes with a symmetric N-heterocyclic carbene ligand (MeNHC) is reported. These complexes were obtained from 1,3-dimethylimidazolium-2-carboxylate, a masked NHC precursor. Their cytotoxicity, oxidative nature, and antibacterial behavior were investigated. The highest cytotoxic effect (IC50 = 1.21 μM) was observed with the cis-[Pt(MeNHC)2Cl2] complex in the cervix cancerous cell line HeLa.

AB - The synthesis of cis and trans geometrical isomers of platinum(ii) complexes with a symmetric N-heterocyclic carbene ligand (MeNHC) is reported. These complexes were obtained from 1,3-dimethylimidazolium-2-carboxylate, a masked NHC precursor. Their cytotoxicity, oxidative nature, and antibacterial behavior were investigated. The highest cytotoxic effect (IC50 = 1.21 μM) was observed with the cis-[Pt(MeNHC)2Cl2] complex in the cervix cancerous cell line HeLa.

UR - http://www.scopus.com/inward/record.url?scp=85134568346&partnerID=8YFLogxK

U2 - 10.1039/d2nj02508f

DO - 10.1039/d2nj02508f

M3 - Artículo

AN - SCOPUS:85134568346

SN - 1144-0546

VL - 46

SP - 14221

EP - 14226

JO - New Journal of Chemistry

JF - New Journal of Chemistry

IS - 29

ER -

Cis and trans platinum(ii) N-heterocyclic carbene isomers: synthesis, characterization and biological activity

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