TY - JOUR
T1 - Chikungunya
T2 - Molecular aspects, clinical outcomes and pathogenesis
AU - Bautista-Reyes, Eduardo
AU - Núñez-Avellaneda, Daniel
AU - Alonso-Palomares, Luis Antonio
AU - Salazar, Ma Isabel
PY - 2017/11/1
Y1 - 2017/11/1
N2 - The alarming worldwide emergence of the chikungunya virus began in the last decade. Since the first autochthonous transmission in Mexico in November of 2014, the virus has spread throughout the country, resulted in multiple outbreaks. This virus produces an acute and self-limiting disease characterized by fever, polyarthralgia, myalgia, exanthema, and general malaise. It is transmitted to humans by the bite of Aedes aegypti and A. albopictus mosquitoes. The fact that the clinical presentation is similar to that produced by other arboviruses complicates its clinical diagnosis. The chronic stage of the disease can cause severe consequences lasting months or years, from local arthralgia to rheumatoid arthritis. In this review, we emphasize the public health threat posed by this highly disabling emerging disease, the clinical outcomes, and its possible physiopathological process. We outline the diagnosis and the impact that this virus has had in Mexico since its introduction.
AB - The alarming worldwide emergence of the chikungunya virus began in the last decade. Since the first autochthonous transmission in Mexico in November of 2014, the virus has spread throughout the country, resulted in multiple outbreaks. This virus produces an acute and self-limiting disease characterized by fever, polyarthralgia, myalgia, exanthema, and general malaise. It is transmitted to humans by the bite of Aedes aegypti and A. albopictus mosquitoes. The fact that the clinical presentation is similar to that produced by other arboviruses complicates its clinical diagnosis. The chronic stage of the disease can cause severe consequences lasting months or years, from local arthralgia to rheumatoid arthritis. In this review, we emphasize the public health threat posed by this highly disabling emerging disease, the clinical outcomes, and its possible physiopathological process. We outline the diagnosis and the impact that this virus has had in Mexico since its introduction.
KW - Chikungunya
KW - Molecular aspects
KW - Pathogenesis
UR - http://www.scopus.com/inward/record.url?scp=85041208803&partnerID=8YFLogxK
U2 - 10.24875/RIC.17002029
DO - 10.24875/RIC.17002029
M3 - Artículo de revisión
C2 - 29265115
SN - 0034-8376
VL - 69
SP - 299
EP - 307
JO - Revista de Investigacion Clinica
JF - Revista de Investigacion Clinica
IS - 6
ER -