TY - JOUR
T1 - Chikungunya in Guerrero, Mexico, 2019 and Evidence of Gross Underreporting in the Region
AU - Nunez-Avellaneda, Daniel
AU - Tangudu, Chandra
AU - Barrios-Palacios, Jacqueline
AU - Salazar, Ma Isabel
AU - Machain-Williams, Carlos
AU - Cisneros-Pano, Jonathan
AU - McKeen, Lauren A.
AU - Blitvich, Bradley J.
N1 - Publisher Copyright:
Copyright © 2021 by The American Society of Tropical Medicine and Hygiene.
PY - 2021/11
Y1 - 2021/11
N2 - The local public health authorities reported nine cases of chikungunya in Mexico in 2019, none of which occurred in Guerrero, a coastal state in the southwest. To test the hypothesis that chikungunya is grossly underreported in Mexico, acute sera were collected from 639 febrile patients from low-income households in Guerrero in 2019 and serologically assayed for chikungunya virus (CHIKV). Analysis of the sera by plaque reduction neutralization test revealed that 181 (28.3%) patients were seropositive for CHIKV. To identify patients with acute CHIKV infections, a subset of serum samples were tested for CHIKV-specific IgM by ELISA. Serum samples from 21 of 189 (11.1%) patients were positive. These patients met the chikungunya case definition established by the WHO. In conclusion, we provide evidence that CHIKV remains an important public health problem in Mexico and that the true number of cases is severely underestimated.
AB - The local public health authorities reported nine cases of chikungunya in Mexico in 2019, none of which occurred in Guerrero, a coastal state in the southwest. To test the hypothesis that chikungunya is grossly underreported in Mexico, acute sera were collected from 639 febrile patients from low-income households in Guerrero in 2019 and serologically assayed for chikungunya virus (CHIKV). Analysis of the sera by plaque reduction neutralization test revealed that 181 (28.3%) patients were seropositive for CHIKV. To identify patients with acute CHIKV infections, a subset of serum samples were tested for CHIKV-specific IgM by ELISA. Serum samples from 21 of 189 (11.1%) patients were positive. These patients met the chikungunya case definition established by the WHO. In conclusion, we provide evidence that CHIKV remains an important public health problem in Mexico and that the true number of cases is severely underestimated.
UR - http://www.scopus.com/inward/record.url?scp=85122772331&partnerID=8YFLogxK
U2 - 10.4269/ajtmh.21-0431
DO - 10.4269/ajtmh.21-0431
M3 - Artículo
C2 - 34460419
AN - SCOPUS:85122772331
SN - 0002-9637
VL - 105
SP - 1281
EP - 1284
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 5
ER -
