TY - JOUR
T1 - Chemical mediators’ expression associated with the modulation of pain in rheumatoid arthritis
AU - Cortes-Altamirano, José Luis
AU - Morraz-Varela, Abril
AU - Reyes-Long, Samuel
AU - Gutierrez, Marwin
AU - Bandala, Cindy
AU - Clavijo-Cornejo, Denise
AU - Alfaro-Rodriguez, Alfonso
N1 - Publisher Copyright:
© 2020 Bentham Science Publishers.
PY - 2020
Y1 - 2020
N2 - Background: The management of pain in patients with rheumatoid arthritis (RA) is a complex subject due to the autoimmune nature of the pathology. Studies have shown that chemical mediators play a fundamental role in the determination, susceptibility and modulation of pain at different levels of the central and peripheral nervous system, resulting in interesting novel molecular targets to mitigate pain in patients with RA. However, due to the complexity of pain physiology in RA cand the many chemical mediators, the results of several studies are controversial. Objective: The aim of this study was to identify the chemical mediators that are able to modulate pain in RA. Method: In this review, a search was conducted on PubMed, ProQuest, EBSCO, and the Science Citation index for studies that evaluated the expression of chemical mediators on the modulation of pain in RA. Results: Few studies have highlighted the importance of the expression of some chemical mediators that modulate pain in patients with rheumatoid arthritis. The expression of TRPV1, ASIC-3, and TDV8 encode ionic channels in RA and modulates pain, likewise, the transcription factors in RA, such as TNFα, TGF-β1, IL-6, IL-10, IFN-γ, IL-1b, mTOR, p21, caspase 3, EDNRB, CGRPCALCB, CGRP-CALCA, and TAC1 are also directly involved in pain perception. Conclusion: The expression of all chemical mediators is directly related to RA and the modulation of pain by a complex intra and extracellular signaling pathway, however, transcription factors are involved in modulating acute pain, while the ionic channels are involved in chronic pain in RA.
AB - Background: The management of pain in patients with rheumatoid arthritis (RA) is a complex subject due to the autoimmune nature of the pathology. Studies have shown that chemical mediators play a fundamental role in the determination, susceptibility and modulation of pain at different levels of the central and peripheral nervous system, resulting in interesting novel molecular targets to mitigate pain in patients with RA. However, due to the complexity of pain physiology in RA cand the many chemical mediators, the results of several studies are controversial. Objective: The aim of this study was to identify the chemical mediators that are able to modulate pain in RA. Method: In this review, a search was conducted on PubMed, ProQuest, EBSCO, and the Science Citation index for studies that evaluated the expression of chemical mediators on the modulation of pain in RA. Results: Few studies have highlighted the importance of the expression of some chemical mediators that modulate pain in patients with rheumatoid arthritis. The expression of TRPV1, ASIC-3, and TDV8 encode ionic channels in RA and modulates pain, likewise, the transcription factors in RA, such as TNFα, TGF-β1, IL-6, IL-10, IFN-γ, IL-1b, mTOR, p21, caspase 3, EDNRB, CGRPCALCB, CGRP-CALCA, and TAC1 are also directly involved in pain perception. Conclusion: The expression of all chemical mediators is directly related to RA and the modulation of pain by a complex intra and extracellular signaling pathway, however, transcription factors are involved in modulating acute pain, while the ionic channels are involved in chronic pain in RA.
KW - Chemical mediators
KW - Ionic channels
KW - Nociception
KW - Pain
KW - Rheumatoid arthritis
KW - Transcription factors
UR - http://www.scopus.com/inward/record.url?scp=85091967717&partnerID=8YFLogxK
U2 - 10.2174/0929867326666190816225348
DO - 10.2174/0929867326666190816225348
M3 - Artículo de revisión
C2 - 31419924
AN - SCOPUS:85091967717
SN - 0929-8673
VL - 27
SP - 6208
EP - 6218
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
IS - 36
ER -