TY - JOUR
T1 - Cellular and molecular mechanisms of viral infection in the human placenta
AU - León-Juárez, Moises
AU - Martínez-Castillo, Macario
AU - González-García, Luis Didier
AU - Helguera-Repetto, Addy Cecilia
AU - Zaga-Clavellina, Verónica
AU - García-Cordero, Julio
AU - Flores-Pliego, Arturo
AU - Herrera-Salazar, Alma
AU - Vázquez-Martínez, Edgar Ricardo
AU - Reyes-Muñoz, Enrique
N1 - Publisher Copyright:
© FEMS 2017.
PY - 2017/10/1
Y1 - 2017/10/1
N2 - The placenta is a highly specialized organ that is formed during human gestation for conferring protection and generating an optimal microenvironment to maintain the equilibrium between immunological and biochemical factors for fetal development. Diverse pathogens, including viruses, can infect several cellular components of the placenta, such as trophoblasts, syncytiotrophoblasts and other hematopoietic cells. Viral infections during pregnancy have been associated with fetal malformation and pregnancy complications such as preterm labor. In this minireview, we describe the most recent findings regarding virus-host interactions at the placental interface and investigate the mechanisms through which viruses may access trophoblasts and the pathogenic processes involved in viral dissemination at the maternal-fetal interface.
AB - The placenta is a highly specialized organ that is formed during human gestation for conferring protection and generating an optimal microenvironment to maintain the equilibrium between immunological and biochemical factors for fetal development. Diverse pathogens, including viruses, can infect several cellular components of the placenta, such as trophoblasts, syncytiotrophoblasts and other hematopoietic cells. Viral infections during pregnancy have been associated with fetal malformation and pregnancy complications such as preterm labor. In this minireview, we describe the most recent findings regarding virus-host interactions at the placental interface and investigate the mechanisms through which viruses may access trophoblasts and the pathogenic processes involved in viral dissemination at the maternal-fetal interface.
KW - Maternal-fetal interface
KW - Trophoblasts
KW - Vertical infection
KW - Viral entry
KW - Viral pathogenesis
KW - Viruses
UR - http://www.scopus.com/inward/record.url?scp=85037060030&partnerID=8YFLogxK
U2 - 10.1093/femspd/ftx093
DO - 10.1093/femspd/ftx093
M3 - Estudio breve
C2 - 28903546
AN - SCOPUS:85037060030
SN - 2049-632X
VL - 75
JO - Pathogens and disease
JF - Pathogens and disease
IS - 7
M1 - ftx093
ER -
